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The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models.
J Ayurveda Integr Med
January 2025
Department of Pharmacy, Universitas Sriwijaya, South Sumatera, Indonesia.
Background: Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. Artocarpus champeden is a traditional medicinal plant that is commonly found in Indonesia.
Objective: This study aims to evaluate the potential of the ethyl acetate fraction of Artocarpus champeden leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.
Exploring the anti-biofilm and gene regulatory effects of anti-inflammatory drugs on Candida albicans.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Researchers have repurposed several existing anti-inflammatory drugs as potential antifungal agents in recent years. So, this study aimed to investigate the effects of anti-inflammatory drugs on the growth, biofilm formation, and expression of genes related to morphogenesis and pathogenesis in Candida albicans. The minimum inhibitory concentration (MIC) of anti-inflammatory drugs was assessed using the broth microdilution method.
View Article and Find Full Text PDFCOVID-19 and severe cutaneous allergic reactions to sulfonamides.
Allergy Asthma Proc
November 2024
From the Section of Allergy, Asthma and Immunology, Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania and.
Sulfonamides are associated with severe cutaneous adverse reactions (SCARs). Coronavirus disease 2019 (COVID-19) triggers an immune response, which may increase the likelihood of developing a hypersensitivity reaction. We sought to explore the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the probability of developing SCARs and/or erythema multiforme (EM) reactions to sulfonamides.
View Article and Find Full Text PDFand parthenolide increase defensive agents and promote antisecretory activity supporting their gastroprotective actions in rodents.
Nat Prod Res
November 2024
Postgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, Santa Catarina, Brazil.
Article Synopsis
- The study investigates the anti-ulcer effects of hydroalcoholic extract (HETp) and its active component parthenolide (PTL) against gastric ulcers induced by ethanol and piroxicam.
- Results showed that both HETp and PTL significantly reduced ulcer formation, with additional histological support confirming their effectiveness.
- The protective effects involve various mechanisms, including the influence of nitric oxide, adrenergic receptors, and prostaglandins, while also enhancing antioxidant levels and reducing harmful enzyme activity.
Therapeutic potential of d-limonene in rheumatoid arthritis: Modulation of inflammatory, anti-inflammatory cytokines, and prostaglandin E2.
Arch Pharm (Weinheim)
December 2024
Laboratory of Biotechnology and Natural Resources Valorizationm, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Rheumatoid arthritis (RA) is a persistent autoimmune disorder predominantly affecting the joint structures, eliciting inflammatory responses, and ultimately leading to degenerative changes without proper medical intervention. Ultimately, this can severely impair joint function and impact the patient's quality of life. Current treatment approaches include disease-modifying anti-rheumatic drugs, non-steroidal anti-inflammatory drug, corticosteroids, and biologic therapies for RA management.
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