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Association between FTO gene polymorphism and obesity in down syndrome children.
Eur J Pediatr
December 2024
Department of Clinical Pathology Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Article Synopsis
- Children with Down syndrome (DS) have a higher prevalence of overweight and obesity compared to their typically developing peers, and this study focuses on a specific gene polymorphism (FTO rs17817449) that may be linked to this issue.
- The research included 100 DS children categorized by their BMI, revealing that those who were overweight or obese had a significantly higher frequency of the FTO rs17817449 T allele and certain genotypes compared to non-obese DS children.
- The findings suggest a clear association between the FTO rs17817449 genetic variant and obesity in DS, identifying specific genotypes and triglyceride levels as independent risk factors for overweight/obesity in this population.
Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome.
J Neurodev Disord
December 2024
Carolina Institute for Developmental Disabilities (CIDD), University of North Carolina at Chapel Hill, 101, Renee Lynne Court, Carrboro, NC, 27510, USA.
Background: Down syndrome (DS) is the most common congenital neurodevelopmental disorder, present in about 1 in every 700 live births. Despite its prevalence, literature exploring the neurobiology underlying DS and how this neurobiology is related to behavior is limited. This study fills this gap by examining cortical volumes and behavioral correlates in school-age children with DS.
View Article and Find Full Text PDFA Pathway-Level Information ExtractoR (PLIER) framework to gain mechanistic insights into obesity in Down syndrome.
Pac Symp Biocomput
December 2024
Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Down syndrome (DS), caused by the triplication of chromosome 21 (T21), is a prevalent genetic disorder with a higher incidence of obesity. Traditional approaches have struggled to differentiate T21-specific molecular dysregulation from general obesity-related processes. This study introduces the omni-PLIER framework, combining the Pathway-Level Information ExtractoR (PLIER) with the omnigenic model, to uncover molecular mechanisms underlying obesity in DS.
View Article and Find Full Text PDFA descriptive analysis of sarcopenia markers in young adults with down syndrome.
Exp Gerontol
January 2025
School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.
Background: Most body composition research in individuals with Down Syndrome (DS) has focused on overweight and obesity. Although limited research has shown muscle mass indexes and physical performance levels of adults with DS are similar to or lower than older adults with sarcopenia, there is still a large gap in the literature regarding sarcopenia.
Objective: This brief report provides a comprehensive descriptive analysis of sarcopenia and obesity markers in individuals with DS.
The effect of health education on quality of life (QOL) among polycystic ovary syndrome (PCOS) females at Karachi, Pakistan.
J Pak Med Assoc
November 2024
Department of Nursing and Midwifery, Dow University of Health Sciences, Karachi, Pakistan.
Objective: To evaluate the effect of nurses-led health education intervention on quality of life among polycystic ovary syndrome females.
Methods: The quasi-experimental study was conducted from May to August 2022 at the Obstetrics and Gynaecology outpatient department of Dow University Hospital, Karachi, and comprised married females aged 18-45 years, who were diagnosed with polycystic ovary syndrome based on the Rotterdam criteria. Nurses-led health education intervention session was conducted for all the patients.
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