Possible role of sialic acid and endogenous neuraminidase in T-cell proliferation.

The proliferation of T cells in MLR with strains C57Bl/6 and DBA2, mouse spleen and lymph node cells was increased when the inhibitors of endogenous neuraminidase was added in the culture. This is in favor of participation of this enzyme and implicitly of terminal sialic acid in the proliferation of T-cells. Ths possibility that the suppressive activity of T-cells might have been abolished is discussed.