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ATRX mutation modifies the DNA damage response in glioblastoma multiforme tumor cells and enhances patient prognosis.
Medicine (Baltimore)
January 2025
Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
The presence of specific genetic mutations in patients with glioblastoma multiforme (GBM) is associated with improved survival outcomes. Disruption of the DNA damage response (DDR) pathway in tumor cells enhances the effectiveness of radiotherapy drugs, while increased mutational burden following tumor cell damage also facilitates the efficacy of immunotherapy. The ATRX gene, located on chromosome X, plays a crucial role in DDR.
View Article and Find Full Text PDFAutoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study.
Biomedicines
December 2024
Unit of Epidemiology & Statistical Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
: While post-acute COVID-19 syndrome is well known and extensively studied, the post-acute COVID vaccination syndrome (PACVS) is a more recent nosological entity that is poorly defined at the immunopathological level, although it shares many symptoms with the sequelae of viral infections. : This single-center retrospective study reports a case series of 17 subjects vaccinated with mRNA or adenoviral vector vaccines who were healthy before vaccination and had never been infected with SARS-CoV-2 but who presented with symptoms similar to PACVS for a median time of 20 months (min 4, max 32). The medical records of all patients referred to our outpatient clinic over a one-year period were retrospectively analyzed.
View Article and Find Full Text PDFImmune checkpoint proteins are associated with persistently high liver stiffness after successful HCV treatment in people with HIV: a retrospective study.
Front Immunol
January 2025
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain.
Article Synopsis
- This study investigated the link between immune checkpoint proteins and liver stiffness in HIV/HCV-coinfected individuals one year after successful HCV treatment, focusing on plasma levels of these proteins and their correlation with liver stiffness measured five years later.
- 39 patients with advanced liver disease who achieved sustained virologic response (SVR) were analyzed, revealing that although liver stiffness decreased over time, it remained persistently high in 61.5% of participants five years after treatment.
- Elevated levels of immune checkpoints BTLA, PD-1, and TIM-3 were associated with this persistently high liver stiffness, indicating a potential ongoing immunological impact on liver health even after HCV eradication.
Comparative assessment of Chlamydia trachomatis pathogen prevalence, and the determination of host gyneco-epidemiological and immunological associated risk factors in female infertility.
Cytokine
January 2025
Department of Neuroscience and Cell Biology, Robert Wood John Medical School, Rutgers, State University of New Jersey, United States.
This study investigates the immunopathological responses to Chlamydia trachomatis (Ct) heat shock protein (Ct-Hsp) and their association with infertility. The objective was to explore the prevalence of anti-Ct antibodies and the gyneco-epidemiological risk factors for infertility among women attending a fertility clinic in Zaria, Nigeria, and to analyze the host immune cytokine or Ct-antigen levels in Ct-positive samples for correlation. From December 2022 to January 2024, 215 women (109 infertile and 106 fertile) from Ahmadu Bello University Teaching Hospital participated in this study.
View Article and Find Full Text PDFGut microbiome and metabolomics in systemic sclerosis: feature, link and mechanisms.
Front Immunol
November 2024
Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Systemic sclerosis (SSc) is a rare and highly heterogeneous chronic autoimmune disease characterized by multi-organ and tissue fibrosis, often accompanied by a poor prognosis and high mortality rates. The primary pathogenic mechanisms of SSc are considered to involve tissue fibrosis, autoimmune dysfunction, and microvascular abnormalities. Recent studies have shed light on the gut microbiota (GM) and metabolites in SSc patients, revealing their association with gastrointestinal symptoms and disease phenotypes.
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