Application of heparin in low doses to the treatment of 6 patients to prevent postoperative venous thromboembolic complications led to the development of an allergic heparin infiltrate (AHI). In three cases, the AHI eventuated in skin and subcutaneous fat necrosis, while in the remaining cases, underwent a reverse development. Apparently, the basis of the AHI is formed by the immediate type hypersensitivity developing in the area of repeated heparin injections. The AHI should be treated with glucocorticoids, antihistamine drugs, and antibiotics.
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Guideline for allergological diagnosis of drug hypersensitivity reactions: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Dermatological Society (DDG), the Association of German Allergologists (ÄDA), the German Society for Pediatric Allergology (GPA), the German Contact Dermatitis Research Group (DKG), the German Society for Pneumology (DGP), the German Society of Otorhinolaryngology, Head and Neck Surgery, the Austrian Society of Allergology and Immunology (ÖGAI), the Austrian Society of Dermatology and Venereology (ÖGDV), the German Academy of Allergology and Environmental Medicine (DAAU), and the German Documentation Center for Severe Skin Reactions (dZh).
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Not available.
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