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Effect of Fluorine Atoms and Piperazine Rings on Biotoxicity of Norfloxacin Analogues: Combined Experimental and Theoretical Study.
Environ Health (Wash)
December 2024
School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266520, China.
To clarify the effect of the fluorine atom and piperazine ring on norfloxacin (NOR), NOR degradation products (NOR-DPs, P1-P8) were generated via UV combined with hydrogen peroxide (UV/HO) technology. NOR degradation did not significantly affect cytotoxicity of NOR against BV2, A549, HepG2, and Vero E6 cells. Compared with that of NOR, mutagenicity and median lethal concentration of P1-P8 in fathead minnow were increased, and bioaccumulation factor and oral median lethal dose of P1-P8 in rats were decreased.
View Article and Find Full Text PDFTreating Burn Infections With Topical Delivery of Positively Charged Norfloxacin-Loaded Lipid-Polymer Hybrid Nanoparticles.
Recent Adv Drug Deliv Formul
December 2024
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11884, Egypt.
Background: Norfloxacin (NFX) is a wide-spectrum antibacterial agent that suffers from low water solubility and first-pass metabolism. This diminishes its oral bioavailability by 60-70%.
Objective: This work aims to formulate a topical gel of NFX-loaded lipid polymer hybrid nanoparticles (NFX-LPHNPs) that combine the merits of liposomes and polymeric nanoparticles to overcome these problems.
Proposed macroscopic quality indicators of antimicrobial stewardship in primary care: An observational study.
Infect Dis Now
December 2024
Hospital hygiene department, Besancon University Hospital, Besancon, France; UMR 6249 Chrono-environnement, University of Bourgogne Franche Comté, Besançon, France.
Article Synopsis
- - The study aimed to assess how effective two macroscopic quality indicators are in improving antibiotic use strategies across the Bourgogne-Franche-Comté region from 2015 to 2020.
- - Data on antibiotic prescriptions for urinary and respiratory infections were analyzed, revealing varying consumption rates among departments and a consistent increase in quality indicator scores, except for urinary infections in 2020 due to a medication shortage.
- - The findings suggest that these quality indicators can effectively identify areas for improvement in antibiotic prescribing practices, helping general practitioners focus on community health needs without requiring detailed diagnostic information.
Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction.
Pharmaceutics
November 2024
Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil.
The work investigates the effect of the estragole complex encapsulated in beta-cyclodextrin (ES/β-CD) in modulating bacterial resistance, specifically in strains expressing NorA and MepA efflux pumps. Efflux pumps are mechanisms that bacteria use to resist antibiotics by expelling them from the cell. Methodology: Several compounds and antibiotics, such as ciprofloxacin and norfloxacin, were used to evaluate the antimicrobial activity and the ability of the ES/β-CD complex to reverse resistance.
View Article and Find Full Text PDFTwo Novel Hydrate Salts of Norfloxacin with Phenolic Acids and Their Physicochemical Properties.
Antibiotics (Basel)
September 2024
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Article Synopsis
- Norfloxacin (NORF) is a widely used fluoroquinolone antibiotic that has limitations due to its poor water solubility and low oral bioavailability.
- This study focuses on improving NORF’s biopharmaceutical properties by creating two new hydrate salts using phenolic acid, namely NORF-3,5-DBA hydrate and NORF-VA hydrate.
- The research shows that these salts significantly enhance NORF's solubility and antibacterial effectiveness, demonstrated by better inhibition of bacteria and reduced minimum inhibitory concentration values.
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