AI Article Synopsis

  • A protein kinase was found in mouse organs, requiring Ca++ and phosphatidylserine for activity at pH 6, indicating it resembles protein kinase C.
  • The specific activity levels were highest in the brain, followed by spleen, lung, and heart, mirroring findings in rat organs.
  • While seven mouse strains exhibited similar protein kinase C activity, strain A/J showed half the activity of others, and hybrid mice from A/J and BALB/cByJ showed intermediate activity levels, suggesting an additive genetic inheritance.

Article Abstract

A protein kinase was identified in mouse organs whose activity is strictly dependent on the presence of Ca++ and phosphatidylserine when assayed at pH 6, and thus has the characteristics of protein kinase C. The relative order of specific activities was brain greater than spleen greater than lung greater than heart, an order similar to that found previously for rat organs. Mice from seven strains had the same level of protein kinase C activity, but strain A/J had half as much activity in each organ as did the other strains. F1 hybrid mice resulting from a cross between A/J and BALB/cByJ mice had levels of activity intermediate to the parental strains, indicating additive inheritance of this genetic difference.

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http://dx.doi.org/10.1016/s0006-291x(84)80060-1DOI Listing

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