A protein kinase was identified in mouse organs whose activity is strictly dependent on the presence of Ca++ and phosphatidylserine when assayed at pH 6, and thus has the characteristics of protein kinase C. The relative order of specific activities was brain greater than spleen greater than lung greater than heart, an order similar to that found previously for rat organs. Mice from seven strains had the same level of protein kinase C activity, but strain A/J had half as much activity in each organ as did the other strains. F1 hybrid mice resulting from a cross between A/J and BALB/cByJ mice had levels of activity intermediate to the parental strains, indicating additive inheritance of this genetic difference.
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http://dx.doi.org/10.1016/s0006-291x(84)80060-1 | DOI Listing |
NMR Biomed
February 2025
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Cellular metabolism is inextricably linked to transmembrane levels of proton (H), sodium (Na), and potassium (K) ions. Although reduced sodium-potassium pump (Na-K ATPase) activity in tumors directly disturbs transmembrane Na and K levels, this dysfunction is a result of upregulated aerobic glycolysis generating excessive cytosolic H (and lactate) which are extruded to acidify the interstitial space. These oncogene-directed metabolic changes, affecting intracellular Na and H, can be further exacerbated by upregulation of ion exchangers/transporters.
View Article and Find Full Text PDFCirc Res
January 2025
Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China (X.H., J.Z., C.X., R.C., P.J., X.J., P.H.).
Background: Cardiac ischemia/reperfusion disrupts plasma membrane integrity and induces various types of programmed cell death. The ESCRT (endosomal sorting complex required for transport) proteins, particularly AAA-ATPase Vps4a (vacuolar protein sorting 4a), play an essential role in the surveillance of membrane integrity. However, the role of ESCRT proteins in the context of cardiac injury remains unclear.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Background: Huntington disease (HD), a neurodegenerative autosomal dominant disorder, is characterized by involuntary choreatic movements with cognitive and behavioral disturbances. Up to now, no therapeutic strategies are available to completely ameliorate the progression of HD. has various pharmacologic effects such as antioxidant and anti-inflammatory activities.
View Article and Find Full Text PDFFront Microbiol
December 2024
Scientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Introduction: WhiA is a conserved protein found in numerous bacteria. It consists of an HTH DNA-binding domain linked with a homing endonuclease (HEN) domain. WhiA is one of the most conserved transcription factors in reduced bacteria of the class Mollicutes.
View Article and Find Full Text PDFFront Plant Sci
December 2024
SD Guthrie Research Sdn. Bhd., Banting, Selangor Darul Ehsan, Malaysia.
Oil palm () yield is impacted by abiotic stresses, leading to significant economic losses. To understand the core abiotic stress transcriptome (CAST) of oil palm, we performed RNA-Seq analyses of oil palm leaves subjected to drought, salinity, waterlogging, heat, and cold stresses. A total of 19,834 differentially expressed genes (DEGs) were identified.
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