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Gold(I)-Catalyzed 2-Deoxy-β-glycosylation via 1,2-Alkyl/Arylthio Migration: Synthesis of Velutinoside A Pentasaccharide.
J Am Chem Soc
January 2025
Molecular Synthesis Center, Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotherapeutics, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
2-Deoxy-β-glycosides are essential components of natural products and pharmaceuticals; however, the corresponding 2-deoxy-β-glycosidic bonds are challenging to chemically construct. Herein, we describe an efficient catalytic protocol for synthesizing 2-deoxy-β-glycosides via either IPrAuNTf-catalyzed activation of a unique 1,2--positioned C2--propargyl xanthate (OSPX) leaving group or (PhO)PAuNTf-catalyzed activation of a 1,2--C2--alkynylbenzoate (OABz) substituent of the corresponding thioglycosides. These activation processes trigger 1,2-alkyl/arylthio-migration glycosylation, enabling the synthesis of structurally diverse 2-deoxy-β-glycosides under mild reaction conditions.
View Article and Find Full Text PDFIs Ockham's razor losing its edge? New perspectives on the principle of model parsimony.
Proc Natl Acad Sci U S A
February 2025
Department of Computer Science, University of Manchester, Manchester M13 9PL, United Kingdom.
The preference for simple explanations, known as the parsimony principle, has long guided the development of scientific theories, hypotheses, and models. Yet recent years have seen a number of successes in employing highly complex models for scientific inquiry (e.g.
View Article and Find Full Text PDFBubble coalescence principle in saline water.
Proc Natl Acad Sci U S A
February 2025
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, China.
Bubbles present in saline water typically exhibit a prolonged lifetime, making them attractive for various engineering processes. Herein, we unveil a transition from delayed bubble coalescence to rapid bursting within about one millisecond in salty solutions. The key aspect in understanding this transition lies in the combined influences of surface deformation and ion surface excess instead of characterizing the ions alone.
View Article and Find Full Text PDFCombining radio-telemetry and radar measurements to test optimal foraging in an aerial insectivore bird.
Elife
January 2025
Department of Evolutionary and Environmental Biology and Institute of Evolution, University of Haifa, Haifa, Israel.
Optimal foraging theory posits that foragers adjust their movements based on prey abundance to optimize food intake. While extensively studied in terrestrial and marine environments, aerial foraging has remained relatively unexplored due to technological limitations. This study, uniquely combining BirdScan-MR1 radar and the Advanced Tracking and Localization of Animals in Real-Life Systems biotelemetry system, investigates the foraging dynamics of Little Swifts () in response to insect movements over Israel's Hula Valley.
View Article and Find Full Text PDFThe Effect of Dietary Propylene Glycol on the Fatty Acid Composition of Three Fat Depots in Male Akkaraman Lambs.
Vet Med Sci
March 2025
Faculty of Veterinary Medicine, Department of Genetics, Hatay Mustafa Kemal University, Hatay, Türkiye.
This study tested the effects of propylene glycol (PG) on the fatty acid composition of Akkaraman lambs in three different anatomical depot locations (ADLs). Twenty-four lambs were assigned to a randomized complete block design comprising three groups of 8 animals as follows: Con, 1.5%, body weight (BW) (PG1.
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