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Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease.
Stroke
February 2024
Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (L.H.C., A.S.-A., J.G.).
Article Synopsis
- Intracranial atherosclerotic disease (ICAD) is a leading cause of stroke, particularly affecting East Asian and non-White populations more than those of European descent.
- ICAD not only raises the risk of stroke but also contributes to dementia and cognitive decline, with a notably high recurrence rate of over 20% for those with severe stenosis (≥70%).
- Diagnosis primarily involves lumen-based imaging techniques, although newer methods like high-resolution vessel wall MRI may improve the identification of ICAD compared to other artery conditions.
Lipoprotein(a) distribution and its association with carotid arteriopathy in the Chinese population.
Atherosclerosis
May 2023
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China; Huanggang Institute of Translation Medicine of Yangtze University, Huanggang, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address:
Background And Aims: The distribution of lipoprotein(a) [Lp(a)] has not been well-studied in a large population in China. The relationship between Lp(a) and carotid atherosclerosis remains undefined. In this study, we aimed to investigate the distribution of Lp(a) levels and to assess their association with carotid arteriopathy in China.
View Article and Find Full Text PDFFemale Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study.
J Atheroscler Thromb
August 2023
Department of Hygiene and Public Health, Teikyo University School of Medicine.
Article Synopsis
- This study investigates how reproductive factors such as gravidity (number of pregnancies) and delivery affect subclinical atherosclerosis in the brain and carotid artery among East Asian women.
- Using MRI and ultrasound data from a cohort of women aged 55 and older, the study found that higher numbers of pregnancies and deliveries were linked to increased risks of brain damage (indicated by white matter hyperintensity) and plaque build-up in the carotid artery.
- However, factors like age at menarche, menopause, and duration of estrogen exposure did not show a significant association with these atherosclerotic changes.
International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches.
Atherosclerosis
August 2022
Department of Vascular Disease, University Medical Center Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Cardiovascular disease (CVD) is the leading cause of mortality and disability in developed countries. According to WHO, an estimated 17.9 million people died from CVDs in 2019, representing 32% of all global deaths.
View Article and Find Full Text PDFUrinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study.
Scand Cardiovasc J
December 2022
Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio (UACR) and subclinical CVD.
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