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Objectives: To describe the clinical presentation and clinicopathological findings of dogs with nodular splenic lesions composed of heterogeneous cell components associated with systemic inflammation and to provide information on the outcome after surgical resection.
Materials And Methods: Medical records were searched for dogs with histologically and immunohistochemically characterised nodular splenic lesions with mixed stromal, histiocytic and lymphoid cells and the presence of systemic inflammatory markers at the time of diagnosis.
Results: Four dogs were included, of which three had an undifferentiated splenic stromal sarcoma and one had a splenic leiomyosarcoma.
Concurrent leiomyosarcoma causing small bowel obstruction in a patient with non-Hodgkin lymphoma.
BMJ Case Rep
January 2025
Colorectal Surgery, Monash Health, Clayton, Victoria, Australia.
Small bowel obstruction (SBO) is a leading cause of general surgery inpatient admissions. SBO is most commonly associated with postoperative adhesions; however, neoplastic SBO is an important differential. Here, we present a case of neoplastic SBO secondary to leiomyosarcoma in a patient with known mature B cell lymphoma.
View Article and Find Full Text PDFResponse rates of pazopanib therapy in metastatic soft tissue sarcoma using real‑world data.
Oncol Lett
March 2025
Department of Medical Oncology, Ege University Faculty of Medicine, Bornova, Izmir 35100, Turkey.
The present study was a retrospective single-center study. A total of 81 patients diagnosed with metastatic soft tissue sarcoma were included who received pazopanib therapy. Clinical data, including age at diagnosis, histological subtype, treatments received before pazopanib, number of metastatic sites at the time of initiation of treatment, progression-free survival and overall survival time under pazopanib treatment, side effects and response evaluation in follow-up imaging after initiation of pazopanib therapy, were recorded.
View Article and Find Full Text PDFPrimary Small Intestinal Leiomyosarcoma Presenting With Small Bowel Perforation: A Case Report.
Cureus
November 2024
Department of General Surgery, University Hospitals Dorset NHS Foundation Trust, Bournemouth, GBR.
Article Synopsis
- - A 75-year-old woman with abdominal pain and elevated inflammatory markers had a CT scan that revealed a perforated mass in her small intestine, leading to surgery and the discovery of a small intestinal leiomyosarcoma (LMS) after initial suspicion of a gastrointestinal stromal tumor (GIST).
- - The diagnosis of LMS is challenging and can often be misclassified as GIST due to similar features; imaging studies like CT can help but are not always conclusive.
- - This case emphasizes the importance of recognizing LMS as a potential cause of bowel perforation, highlighting the need for accurate diagnosis, multidisciplinary management, and long-term follow-up due to the high risk of recurrence and metastasis.
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