Ipratropium is a parasympatholytic agent with high topical activity. The effect of intranasal ipratropium was studied in 34 patients who were over 60 years of age and who suffered from chronic watery vasomotor rhinorrhoea. The study was a double-blind cross-over placebo controlled trial. Trial parameters were: daily nasal symptom and side effect scores, nasal methacholine testing before and after treatment, and clinical evaluation. The active drug clearly reduced nasal discharge. Nasal methacholine testing showed reduction of nasal secretion after the active treatment period. The majority of the patients preferred the active drug to the placebo. Excessive drying of the nasal mucosa was the most common side effect. Ipratropium seems to have a beneficial effect on vasomotor rhinitis, which often is an irritating condition in elderly patients.
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http://dx.doi.org/10.1111/j.1365-2273.1983.tb01441.x | DOI Listing |
Vestn Otorinolaringol
November 2024
St. Luke Lugansk State Medical University, Lugansk, Russia.
Unlabelled: To reduce the inflammatory reaction that occurs in the nasal mucosa after surgical interventions, it seems promising to develop methods of preventive preparation of the epithelium to the effects of damaging factors in the preoperative period.
Objective: To evaluate the effectiveness of the protective effect of sodium deoxyribonuclease solution on the nasal mucosa in the preoperative period in rhinological patients.
Material And Methods: 71 patients were examined after septoplasty with vasotomy of the lower nasal concha for curvature of the nasal septum and vasomotor rhinitis.
Sci Rep
November 2024
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250022, China.
Glob Epidemiol
December 2024
Department of Epidemiology, UTHealth Science Center at Houston, School of Public Health, Center for Pediatric Population Health, Department of Pediatrics at McGovern Medical School, Houston, USA.
Background: Multimorbidity has emerged as a challenge for health systems due to its association with adverse clinical outcomes. Given the limited information available on multimorbidity, particularly in low- and middle-income countries, this study characterizes multimorbidity patterns in the population of Bogotá, Colombia in 2018.
Methods: In a cross-sectional study, we analyzed 16 million medical consultation records from Bogotá reported in the National Service Delivery Records in 2018.
Braz J Otorhinolaryngol
November 2024
Affiliated Hospital of Southwest Medical University, Department of Otolaryngology Head and Neck Surgery, Sichuan, China. Electronic address:
Objective: Continuous research on the structure and function of intestinal microecology has confirmed the association between gut microbiota and the occurrence, development, and outcome of allergic diseases. Here, we explored the genetic causality between gut microbiota and rhinitis.
Methods: We conducted a two-sample Mendelian Randomization (MR) study to investigate the genetic causal relationship between gut microbiota and allergic rhinitis and vasomotor rhinitis.
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