Differential pulse voltammetry was used for the detection of 5-hydroxyindoles in the cerebral cortex of rats anaesthetized with urethane. The stimulation of the lateral hypothalamus or of the dorsal raphe nucleus induced a 10-40% increase in the amplitude of the signal. The signal recorded from p-chlorophenylalanine (pCPA)-pretreated animals was much smaller than in normal animals and could be increased by 5-HTP administration. The stimulation of the serotonergic pathways was ineffective in the pCPA-pretreated animals.
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