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Optimal Stopping Ages for Colorectal Cancer Screening.
JAMA Netw Open
December 2024
Department of Public Health, Erasmus University Medical Center, Rotterdam, South Holland, the Netherlands.
Importance: Prior studies have shown that the benefits, harms, and costs of colorectal cancer (CRC) screening at older ages are associated with a patient's sex, health, and screening history. However, these studies were hypothetical exercises and not directly informed by data on CRC risk.
Objective: To identify the optimal stopping ages for CRC screening by sex, comorbidity, and screening history from a cost-effectiveness perspective.
Objective: The effectiveness of behavioral interventions is typically evaluated relative to control conditions using null hypothesis significance testing (i.e., < .
View Article and Find Full Text PDFColorectal cancer prevalence in faecal immunochemical test non-returners: potential for health inequality in symptomatic referral pathways.
BJS Open
September 2024
Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Article Synopsis
- The study evaluated the non-return rate of faecal immunochemical tests among patients referred for high-risk colorectal cancer symptoms, finding that 11.9% of 7345 patients did not submit their tests.
- Non-returners tended to be younger, predominantly male, and from lower socioeconomic backgrounds, and they exhibited different clinical outcomes compared to those who returned the test.
- Despite a higher prevalence of colorectal cancer in those who underwent investigations, the overall cancer prevalence was similar between returners and non-returners over a median follow-up of 25 months, indicating potential issues in care access or follow-up for non-returners.
The Tan-Re-Qing Capsule mitigates acute lung injury by suppressing the NLRP3 inflammasome and MAPK/NF-κB signaling pathways.
Gene
January 2025
Department of Respiratory Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
Article Synopsis
- The Tan-Re-Qing Capsule (TRQC) is a traditional Chinese medicine used to treat acute lung injury (ALI) and COVID-19-related issues, and this study investigates its effects on LPS-induced ALI in mice.
- Results showed that TRQC significantly reduced inflammation and injury in ALI models by targeting inflammation-related signaling pathways like NF-κB and MAPK.
- The study suggests that TRQC may be a promising treatment for inflammatory lung diseases, highlighting its potential to inhibit harmful inflammatory responses and assist in healing.
Laboratory considerations in the assessment of 25-hydroxyvitamin D in pregnant women by automated immunoassays.
Pract Lab Med
November 2024
Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Background: Because of the pathophysiological role of vitamin D in health, there is an increased interest to check the clinical status of this vitamin. Immunochemical assays are commonly employed to determine 25-hydroxyvitamin D (25 (OH) D) in clinical laboratories and its testing could be influenced by pre-analytic and analytic issues. The aim of this study was to compare the 25(OH)D results obtained from three commonly used immunoassays in pregnant women to check a possible discrepancy between tests.
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