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universal stress protein contributes to persistence during growth arrest and paraquat-induced superoxide stress.
J Bacteriol
January 2025
Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Unlabelled: is one of the most virulent bacterial pathogens known and causes the disease tularemia, which can be fatal if untreated. This zoonotic and intracellular pathogen is exposed to diverse environmental and host stress factors that require an appropriate response to survive. However, the stress tolerance mechanisms used by to persist are not fully understood.
View Article and Find Full Text PDFReversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies.
J Funct Morphol Kinesiol
January 2025
Open Source Medicine OÜ, 6-15 13517 Talinn, Estonia.
: Age-related decline in musculoskeletal function is a significant concern, particularly in Western countries facing demographic shifts and increased healthcare demands. This review examines the typical trajectories of musculoskeletal deterioration with age and evaluates the effectiveness of various interventions in preventing or reversing these changes. : The review analyzes documented rates of decline across multiple parameters, including muscle mass, Type II muscle fiber reduction, and decreased motor unit firing rates.
View Article and Find Full Text PDFParticipation as a Pillar of Active Ageing: The Role of Eudaimonic Psychological and Health Factors.
Geriatrics (Basel)
January 2025
Department of Psychology of the Personality, Evaluation and Psychological Treatments, Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain.
With ageing population projections, promoting positive ageing trajectories is critical. While health is often emphasised, eudaimonic psychological factors remain underexamined. A qualitative study presented throughout the main text highlighted the importance of psychological factors like purpose in life and resilience in fostering participation and subjective well-being, even amidst declining health.
View Article and Find Full Text PDFEngineering a high-throughput clone for industrial-scale production of long-acting GLP-1 analogue with retained bio-efficacy.
Biotechnol Prog
January 2025
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Type 2 diabetes mellitus (T2DM) and obesity are critical global health issues with rising incidence rates. Glucagon-like peptide-1 (GLP-1) analogues have emerged as effective treatments due to their ability to regulate blood glucose levels and gastric emptying through central nervous signals involving hypothalamic receptors, such as leptin. To address the short plasma half-life of native GLP-1, a C-16 fatty acid was conjugated to lysine in the GLP-1 analogue sequence to enhance its longevity.
View Article and Find Full Text PDFBackground: Escalating pyrethroid resistance in malaria vectors highlights the urgency of implementing new control tools incorporating non-pyrethroid molecules. Here, using DNA-based metabolic resistance markers, we assessed the efficacy of the dual active ingredients net Royal Guard against pyrethroids-resistant malaria vectors in Cameroon, establishing its long-term impact on mosquitoes' life traits after exposure.
Results: Cone assays revealed low efficacy of Royal Guard against field Anopheles populations.
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