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The area of exercise-associated ischemia in coronary patients was shown to depend on both total heart arterial damage and functional status of the myocardium. Stress related electrocardiographic ST depression in a limited number of leads was associated with satisfactory myocardial function. Generalized exercise-induced ischemia developed where left-ventricular myocardial function was disturbed significantly. Changes in erythrocyte calcium concentrations were the greatest in those patients whose myocardial function was disordered considerably.

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