We have studied the NK activity after either interferon action or not, in total lymphocyte populations, as well as in cellular populations enriched with NK activity. (LGL = 76 +/- 13%). The incubation with interferon lasts 16 hours at 37 degrees C. The result obtained is an increase of the NK activity of the total lymphocyte population, while the cellular population, formerly enriched with NK activity, is not affected. These results are in favour of a necessary cellular cooperation on the interferon action on NK cells.
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