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Effectiveness of Isotretinoin Administration in Rhinoplasty: A Systematic Review.
Facial Plast Surg Aesthet Med
January 2025
Division of Facial Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA.
To investigate the effectiveness of isotretinoin use in patients with thick nasal skin to improve rhinoplasty outcomes. The Population Intervention Comparison Outcome framework was utilized for selecting relevant studies for review. The databases of Medline, Embase, Cinahl, Central, Scopus, and Web of Science were searched in June 2024.
View Article and Find Full Text PDFThe Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study.
Clin Cosmet Investig Dermatol
January 2025
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Introduction: Acne vulgaris, a prevalent dermatological condition, often results in long-term complications such as scarring and hyperpigmentation. While extensive research has focused on treatment modalities, there is a notable gap in understanding the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).
Purpose: This study was conducted to identify the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).
Evaluation of the safety and efficacy of isotretinoin in treatment of COVID-19: A randomized controlled clinical trial.
Contemp Clin Trials
January 2025
Department of Chest Diseases (Internal Medicine), Faculty of medicine, Suez Canal University, Ismailia, Egypt.
The pandemic of SARS-CoV2 is not only limited to the health issues and fatalities encountered in a worldwide overwhelming burden but also the social, economic, and well-being devastation. Many trials were done to find a safe and reliable therapy for COVID-19. Isotretinoin was reported as a possible therapy for COVID-19 through the mining of post-transcriptomic and genomic datasets, which revealed isotretinoin as a potent down-regulator of the ACE2 protein the crucial gateway of SARS-CoV2 to hijack host cells.
View Article and Find Full Text PDFA comparison of iPLEDGE requirements to risk mitigation programs for isotretinoin in other countries and to other teratogenic medications in the United States.
J Am Acad Dermatol
January 2025
The George Washington University School of Medicine and Health Sciences, Department of Dermatology, Washington, DC 20052; Children's National Hospital, Division of Dermatology, Washington, DC 20010.
Background: Acne is an inflammatory skin disease afflicting the majority of the world's population at some point in their lifetime, and is seen to be chronic in about 50% of cases. Acne leads to significant social withdrawal, depression, and disfiguring scars in many cases. Available treatments are characterized by high rates of relapse, dangerous side effects, and social stigma, which often leads to poor patient compliance and treatment failure.
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