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Genetic and Functional Characterization of Toll-Like Receptor Responses in Immunocompetent Patients With CMV Mononucleosis.
Front Cell Infect Microbiol
June 2021
Unit of Microbiology, St. Orsola-Malpighi University Hospital, Bologna, Italy.
Human cytomegalovirus (CMV) modulates both innate and adaptive immune responses. However, limited data are available on the role of receptors of innate immunity, such as toll-like receptors (TLRs) in contributing to antiviral responses and inflammation. The aim of this translational study was to characterize TLR responses in immunocompetent patients with primary and symptomatic CMV infection.
View Article and Find Full Text PDFThe authors report a patient who developed a mononucleotic syndrome after 2 months treatment with diphenylhydantoin. The clinical and biological criteria needed to establish the diagnosis of pseudomononucleosis are listed, while other possible causes described in the literature have been excluded. Complications which may occur during anti-convulsant therapy with diphenylhydantoin are reviewed and the few cases of pseudomononucleosis in the literature noted.
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