Two young homosexual men apparently without any obvious cause of immunosuppression suddenly developed a series of opportunistic infections. Two others presented with prolonged fever and multiple lymph node enlargement of obscure origin. Immunological investigations in these 4 patients showed skin anergy and inversion of helper/suppressor lymphocyte ratio. Proliferative responses to mitogenic agents, soluble antigens and allogenic cells were altered only in the 2 patients with opportunistic infections. Humoral immunity seemed to be preserved in all cases. These 4 patients had previously suffered from many sexually-transmitted infections, had spent some time in the United States and had signs of past or present cytomegalovirus infection. As in the U.S.A., where this "acquired immunodeficiency syndrome" suddenly developed during the past 2 years, one may suspect, among several hypotheses, that it is caused by a transmissible agent now present in France.
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J Clin Med
December 2024
Department of Surgery IV, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania.
In recent decades, the advantages of minimizing surgical trauma have led to the development of minimally invasive surgical procedures. While the benefits often outweigh the risks, several challenges are encountered that are not present in conventional surgical approaches. Unilateral pulmonary edema (UPE) after mitral interventions performed through a right-sided approach is a rare but potentially life-threatening event.
View Article and Find Full Text PDFBackground: Long QT Syndrome Type-2 (LQT2) is due to loss-of-function variants. encodes K 11.1 that forms a delayed-rectifier potassium channel in the brain and heart.
View Article and Find Full Text PDFCureus
December 2024
Orthopaedic Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, JPN.
A 41-year-old man with a history of obesity, hypertension, and smoking suffered from numbness and weakness in both lower limbs. He was diagnosed with ossification of the posterior longitudinal ligament and ligamentum flavum in the cervical and thoracic spine by X-rays, CT, and MRI. The patient underwent laminectomies at T2 and T3 levels, along with posterior fusion from T1 to T4, to address an upper thoracic spine lesion causing sensory deficits up to T5 and gait disturbances.
View Article and Find Full Text PDFJ Cardiothorac Surg
January 2025
Department of Traditional Chinese Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Malignant esophageal mediastinal fistula is a severe complication that occurs in both the advanced stages of esophageal cancer and after radiotherapy for esophageal cancer. Esophageal mediastinal fistula is very susceptible to complications such as mediastinitis and mediastinal abscess, resulting in a significantly elevated mortality rate for patients. We reported a rare case of esophageal mediastinal fistula after immunotherapy for non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFAust Vet J
December 2024
Centre for Veterinary Education, Sydney School of Veterinary Science, The University of Sydney, Sydney, Australia.
A 12-year-old Bengal cat with unclassified cardiomyopathy presented for signs consistent with aortic thromboembolism (ATE). It was treated with clopidogrel and rivaroxaban as antithrombotic therapy, combined with narcotic analgesia and frusemide. After initially making a clinical improvement, the cat's condition suddenly deteriorated, with a presumptive diagnosis of clostridial myonecrosis.
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