The authors describe a new device for weaning from mechanical ventilation, based on continuous measurement of end-expiratory concentration of CO 2 (FCO 2 ET). The spontaneous or controlled mode of ventilation is automatically determined by the level of FCO 2 ET in relation to preselected maximum and minimum thresholds. The authors call this device "CO 2MV".
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JAMA Health Forum
January 2025
Department of Health Policy and Management, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Importance: Skilled nursing facilities (SNFs) experienced high mortality during the COVID-19 pandemic, leading them to adopt preventive measures to counteract viral spread. A critical appraisal of these measures is essential to support SNFs in managing future infectious disease outbreaks.
Objective: To perform a scoping review of data and evidence on the use and effectiveness of preventive measures implemented from 2020 to 2024 to prevent COVID-19 infection in SNFs in the US.
Crit Care Explor
February 2025
Division of Critical Care Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Importance: While corticosteroid administration in septic shock has been shown to result in faster shock reversal and lower short-term mortality, the role of corticosteroids in the management of cardiogenic shock (CS) remains unexplored.
Objectives: Determine the impact of corticosteroid administration on 90-day mortality (primary outcome) in patients admitted to a critical care unit with CS.
Design, Setting, And Participants: In this retrospective cohort study, we used the critical care database of Medical Information Mart for Intensive Care-IV, and included all adult patients diagnosed with CS excluding repeated admissions, patients with adrenal insufficiency, those receiving baseline corticosteroids, and those requiring extracorporeal life support.
Scand J Med Sci Sports
February 2025
School of Kinesiology, The University of Western Ontario, London, Ontario, Canada.
We assessed the validity, reliability, and transferability of gas exchange and ventilatory variables from two commonly used metabolic measurement systems (COSMED Quark and VO2Master Pro). Two identical devices from each system were independently connected to a metabolic simulator (VacuMed), and 2 min of steady-state data was recorded at simulated oxygen uptake (V̇O) of 1, 2, 3, and 4 L∙min achieved through minute ventilation (V̇) of 30, 60, 105, and 150 L∙min. Each metabolic analyzer recorded data three times for each "intensity" in a randomized order, and assessments were completed on two separate days.
View Article and Find Full Text PDFNurs Crit Care
January 2025
Guy's & St Thomas' NHS Foundation Trust, London, UK.
Background: Energy usage is one of the largest contributors to health care carbon emissions. By taking a strategic, targeted approach in one of the most energy-intensive units of a hospital, the potential for energy savings is real and significant.
Aim: To develop a protocol for the implementation of interventions to reduce the environmental impact of carbon emissions generated by an adult intensive care unit (AICU) in a London-based hospital setting.
Cureus
December 2024
Pulmonology and Critical Care, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Malignant hyperthermia is a pharmacogenetic disorder that manifests clinically as a hypermetabolic crisis when a patient with a mutation in the ryanodine or dihydropyridine receptor genes is exposed to neuromuscular blocking agents. Depolarizing neuromuscular agents are known to cause malignant hyperthermia, but cases caused by nondepolarizing agents are rarely reported. We present a case consistent with malignant hyperthermia after receipt of cisatracurium, a nondepolarizing anesthetic agent.
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