Bone induction occurs with about 100% frequency around both the auto- and homotransplants of the guinea-pig transitional epithelium. In most cases the bone that developed around the epithelium disappears after immunological resorption of the homotransplanted epithelium. It was found from experiments with the mixed auto- and homological epithelium that the immunological response itself is not responsible for resorption of the induced bone tissue. The results obtained also show that the induced bone formed by recipients' rather than by donors' cells is the inductor-dependent, i. e. self-maintenance of the induced bone requires continuous inducing stimulation from the epithelium.

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