AI Article Synopsis
- Five acute schizophrenic patients were administered a standard dose of thioridazine (4 mg/kg/day) and monitored for plasma levels and ECG changes.
- Four out of five patients exhibited abnormal ECG readings linked to elevated levels of thioridazine ring sulfoxide.
- No correlation was found between ECG abnormalities and the levels of thioridazine or its other metabolites.
Article Abstract
Five acute schizophrenic patients were given a standard thioridazine dose (4 mg/kg/day po). Their plasma concentrations of thioridazine and its metabolites were determined by GLC, and their ECG's were recorded routinely. In four of the five patients, abnormal ECG's (malformation of the T-wave or lengthening of the repolarization time) were found whenever plasma concentrations of the thioridazine ring sulfoxide were elevated. No relationship could be detected between the appearance of ECG abnormalities and the concentrations of thioridazine and its other metabolites.
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| http://dx.doi.org/10.1002/jps.2600670208 | DOI Listing |
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