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The Impact of HIV on B Cell Compartment and Its Implications for COVID-19 Vaccinations in People with HIV.
Vaccines (Basel)
December 2024
Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
HIV causes intense polyclonal activation of B cells, resulting in increased numbers of spontaneously antibody-secreting cells in the circulation and hypergammaglobulinemia. It is accompanied by significant perturbations in various B cell subsets, such as increased frequencies of immature/transitional B cells, activated memory B cells, atypical memory B cells, short-lived plasmablasts and regulatory B cells, as well as by decreased frequencies of resting memory and resting naïve B cells. Furthermore, both memory and antigen-inexperienced naïve B cells show exhausted and immune-senescent phenotypes.
View Article and Find Full Text PDFAuthor Correction: Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine.
NPJ Vaccines
November 2024
GreenLight Biosciences Inc., 29 Hartwell Avenue, Lexington, MA, 02421, USA.
Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients.
Life Sci Alliance
December 2024
Laboratory of Human Immunology (Single Cell Genomics), Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Whereas severe COVID-19 is often associated with elevated autoantibody titers, the underlying mechanism behind their generation has remained unclear. Here we report clonal composition and diversity of autoantibodies in humoral response to SARS-CoV-2. Immunoglobulin repertoire analysis and characterization of plasmablast-derived monoclonal antibodies uncovered clonal expansion of plasmablasts producing cardiolipin (CL)-reactive autoantibodies.
View Article and Find Full Text PDFMajor vault protein directly enhances adaptive immunity induced by Influenza A virus or indirectly through innate immunity.
Biochim Biophys Acta Mol Basis Dis
October 2024
State Key Laboratory of Virology, Modern Virology Research Center, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China; Institute of Myocardial Injury and Repair, Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430072, China; Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan 430072, China; Department of General Surgery, Ganzhou Key Laboratory of Thyroid Cancer, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, China. Electronic address:
Article Synopsis
- Major vault protein (MVP) is essential for innate immune responses, but its role in adaptive immunity was unclear until this study.
- The research found that mice without MVP (Mvp knockout) had weaker antibody responses and lower survival rates when faced with the influenza A virus again, compared to normal mice.
- MVP enhances germinal center (GC) responses for better antibody production and supports T cell activation, indicating its crucial role in developing effective immunity against influenza.
Coxsackievirus B1 (CVB1) is a common cause of acute and chronic myocarditis, dilated cardiomyopathy and aseptic meningitis. However, no CVB-vaccines are available for human use. In this study, we investigated the immunogenicity of virus-like particle (VLP) and inactivated whole-virus vaccines for CVB1 when administrated to mice via either subcutaneous or intranasal routes formulated with and without commercial and experimental adjuvants.
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