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Nanotechnology in Parkinson's Disease: overcoming drug delivery challenges and enhancing therapeutic outcomes.
Drug Deliv Transl Res
January 2025
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
The global prevalence of Parkinson's Disease (PD) is on the rise, driven by an ageing population and ongoing environmental conditions. To gain a better understanding of PD pathogenesis, it is essential to consider its relationship with the ageing process, as ageing stands out as the most significant risk factor for this neurodegenerative condition. PD risk factors encompass genetic predisposition, exposure to environmental toxins, and lifestyle influences, collectively increasing the chance of PD development.
View Article and Find Full Text PDFIntralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
Drug Deliv Transl Res
January 2025
Kinimmune, Inc. St. Louis, 63141, Missouri, USA.
PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.
View Article and Find Full Text PDFRisks and rates, and the mathematical link between them.
Eur J Epidemiol
January 2025
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, H3A 1G1, Canada.
The risk over a given time span can be calculated as one minus the exponentiated value of the negative of the integral of the incidence density function (or hazard rate function) over that time span. This relationship is widely used but, in the few instances where textbooks have presented it, the derivations of it tend to be purely mathematical. I first review the historical contexts, definitions, distinctions and links.
View Article and Find Full Text PDFPartners' Perspectives on the Impact of Cancer on Romantic Relationships and Marriage in Adolescent and Young Adult Cancer Survivors.
J Adolesc Young Adult Oncol
January 2025
University of Tsukuba, Tokyo, Japan.
This study aims to explore the impact of cancer on romantic relationships and marriage from the perspective of partners of adolescent and young adult (AYA) cancer survivors. Semistructured interviews were conducted with 10 partners, of any gender and cancer type, who entered into a relationship or decided to marry after the AYA's cancer diagnosis. Three key themes emerged regarding the impact of cancer on romantic relationships and marriage: no change or impact, positive impact, and anxiety.
View Article and Find Full Text PDFDaily Cognition in the Family Context: The Complex Associations between Memory Lapses, Family Relationships, and Affect in Middle-Aged and Older Adults.
Gerontologist
January 2025
Department of Psychology, Clemson University, Clemson, South Carolina, USA.
Background And Objectives: The analysis of daily memory lapses is an underutilized approach to understanding daily experiences of cognitive functioning. The present study adopts this approach, with the goals of exploring how the quality of family relationships predicts the frequency of daily memory lapses and moderates the link between daily memory lapses and daily affect.
Research Design And Methods: We used longitudinal data from the third wave of Midlife in the United States and the National Study of Daily Experiences to assess our research goals.
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