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Characterization of the polysaccharide schizophyllan and schizophyllan-chitosan hydrogel formation by diffusing-wave spectroscopy.
Carbohydr Polym
March 2025
Biophysics and Medical Technology, Department of Physics, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Schizophyllan (SPG) is a semi-flexible, triple-helical polysaccharide with attractive properties as an efficient viscosifying compound and biological response modifier. We report microrheological characterization of schizophyllan as dispersed in solution and the changes associated when crosslinked with chitosan over an extended frequency range using diffusing wave spectroscopy (DWS). A SPG with high molecular weight (M = 1.
View Article and Find Full Text PDFConformational switches in human RNA binding proteins involved in neurodegeneration.
Biochim Biophys Acta Gen Subj
January 2025
Computational Structural Biology Laboratory, Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India; Bioinformatics Centre, Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address:
Conformational switching in RNA binding proteins (RBPs) is crucial for regulation of RNA processing and transport. Dysregulation or mutations in RBPs and broad RNA processing abnormalities are related to many human diseases including neurodegenerative disorders. Here, we review the role of protein-RNA conformational switches in RBP-RNA complexes.
View Article and Find Full Text PDFSTIPS algorithm enables tracking labyrinthine patterns and reveals distinct rhythmic dynamics of actin microridges.
Phys Biol
January 2025
Department of Biological Sciences, Tata Institute of Fundamental Research Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha road, Navy Nagar, Colaba, Mumbai-400005, INDIA, Mumbai, 400005, INDIA.
Tracking and motion analyses of semi-flexible biopolymer networks from time-lapse microscopy images are important tools that enable quantitative measurements to unravel the dynamic and mechanical properties of biopolymers in living tissues, crucial for understanding their organization and function. Biopolymer networks are challenging to track due to continuous stochastic transitions, such as merges and splits, which cause local neighbourhood rearrangements over short time and length scales. To address this, we propose the STIPS algorithm (Spatio Temporal Information on Pixel Subsets) to track these events by creating pixel subsets that link trajectories across frames.
View Article and Find Full Text PDF[Treatment tactics in children with crown-root fractures of permanent teeth].
Stomatologiia (Mosk)
December 2024
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
The main principles of management of children with root fractures of permanent teeth in the coronal third are presented using two clinical cases as an example. In the treatment of root fractures in the coronal third, an important condition for success is timely flexible or semi-flexible splinting of the tooth for a sufficiently long period (up to 4 months). In the absence of splinting or significant mobility of the coronal fragment after removal of the splint the probability of pulp necrosis is very high, and the method of choice is treatment with calcium silicate cements with their introduction by orthograde or surgical access.
View Article and Find Full Text PDFCorrection: Elucidating the influence of side chains on the self-assembly of semi-flexible mesogens.
Chem Commun (Camb)
January 2025
Institut de Sciences des Matériaux de Mulhouse, CNRS UMR 7361, 15 rue Jean Starcky, 68057 Mulhouse, France.
Correction for 'Elucidating the influence of side chains on the self-assembly of semi-flexible mesogens' by Raluca I. Gearba , , 2025, https://doi.org/10.
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