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Maternal exercise before and during pregnancy protects against genotoxicity and promotes offspring hippocampal health in mice prenatally exposed to high fructose.
Mutagenesis
January 2025
Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil.
The fetal brain is susceptible to programming effects during pregnancy, potentially leading to long-term consequences for offspring's cognitive health. Fructose intake is thought to adversely affect fetal brain development, whereas physical exercise before and during pregnancy may be protective. Therefore, this study aimed to assess biochemical and genotoxic changes in maternal hippocampi and behavioral, genotoxic, and biochemical alterations in offspring hippocampi.
View Article and Find Full Text PDFPrenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort.
Ecotoxicol Environ Saf
December 2024
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Department of Maternal and Child Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:
Neurotoxicity of organophosphate esters (OPEs) and organophosphorus pesticides (OPPs) has been documented in toxicological studies, though epidemiological evidence remains inconsistent. The developing fetal brain is susceptible to environmental exposures. Thus, we aim to investigate how prenatal exposure to OPEs and OPPs as mixture affects offspring neurodevelopment in preschool-aged children.
View Article and Find Full Text PDFGlucocorticoid-Dependent Retinal Degeneration and Vision Impairment in Mice Susceptible to Prenatal Stress-Induced Behavioral Abnormalities.
Cell Mol Neurobiol
December 2024
Laboratory of Veterinary Biochemistry, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, South Korea.
Chronic exposure to prenatal stress can impair neurogenesis and lead to irreversible cognitive and neuropsychiatric abnormalities in offspring. The retina is part of the nervous system; however, the impacts of prenatal stress on retinal neurogenesis and visual function remain unclear. This study examined how elevated prenatal glucocorticoid levels differentially affect retinal development in the offspring of pregnant mice exposed to chronic unpredictable mild stress (CUMS).
View Article and Find Full Text PDFExposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review.
Environ Health Insights
November 2024
African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Choba, Nigeria.
This systematic review investigates the association between environmental pollutants and the risk of diarrhea, a critical public health issue, particularly in low- and middle-income countries. The review synthesizes findings from various studies that highlight the impact of contaminants such as pesticides, heavy metals, polycyclic aromatic hydrocarbons (PAHs), microplastics, and parabens on gastrointestinal health. Following PRISMA guidelines, a comprehensive literature search across databases including PubMed, Scopus, and Google Scholar yielded 496 articles, of which 11 met the inclusion criteria for detailed analysis.
View Article and Find Full Text PDFAccidental Detection of Cocaine in Urine in Pediatric Patients: Case Series and Literature Review.
Children (Basel)
October 2024
Responsible GAIA Service, Meyer Children's Hospital IRCCS, Viale Pieraccini 24, 50139 Florence, Italy.
Infantile occult exposure to cocaine in domestic environments represents a complex clinical and medico-legal problem, which can be associated with abuse and neglect and with potential short- and long-term health risks for children. The authors present a retrospective study on 764 children under 14 years old who accessed the Emergency Department of IRCCS Meyer from 2016 to 2023 and were included in the GAIA (Child and Adolescent Abuse Group) protocol for suspected maltreatment and abuse, and for which a urine toxicology analysis was performed. The aim is to discuss the medico-legal implications and highlight the need for a thorough evaluation and management of such situations.
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