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Heatstroke characteristics and meteorological conditions in Hefei, China: thresholds and driving factors.
BMC Public Health
January 2025
Key Laboratory of Cities Mitigation and Adaptation to Climate Change in Shanghai (CMACC), Shanghai, 200092, China.
Background: Due to climate change and rapid urbanization, the frequency of heatwave events in East China has increased considerably since the 21st century, which has a considerable influence on human health, such as heatstroke. However, few studies have been conducted in this region on the relationship between heatstroke and meteorological conditions. To address this point, this study aimed to analyze the characteristics of heatstroke and their relationship with meteorological conditions in Hefei, China.
View Article and Find Full Text PDFStructural basis for human NKCC1 inhibition by loop diuretic drugs.
EMBO J
January 2025
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112-5650, USA.
Na-K-Cl cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are first-line medicines for the treatment of edema and hypertension. NKCC1 activation by the molecular crowding sensing WNK kinases is critical if cells are to combat shrinkage during hypertonic stress; however, how phosphorylation accelerates NKCC1 ion transport remains unclear.
View Article and Find Full Text PDFSoliton solutions of the (2 + 1)-dimensional Jaulent-Miodek evolution equation via effective analytical techniques.
Sci Rep
January 2025
Department of Mathematics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, 602105, India.
In this study, we investigate the [Formula: see text]-D Jaulent-Miodek (JM) equation, which is significant due to its energy-based Schrödinger potential and applications in fields such as optics, soliton theory, signal processing, geophysics, fluid dynamics, and plasma physics. Given its broad utility, a rigorous mathematical analysis of the JM equation is essential. The primary objective of this work is to derive exact soliton solutions using the Modified Sub-Equation (MSE) and Modified Auxiliary Equation (MAE) techniques.
View Article and Find Full Text PDFBiological correlates associated with high-risk breast cancer patients identified using a computational method.
NPJ Breast Cancer
January 2025
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Using a novel unsupervised method to integrate multi-omic data, we previously identified a breast cancer group with a poor prognosis. In the current study, we characterize the biological features of this subgroup, defined as the high-risk group, using various data sources. Assessment of three published hypoxia signatures showed that the high-risk group exhibited higher hypoxia scores (p < 0.
View Article and Find Full Text PDFSex-Based Bias in Artificial Intelligence-Based Segmentation Models in Clinical Oncology.
Clin Oncol (R Coll Radiol)
January 2025
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
Artificial intelligence (AI) advancements have accelerated applications of imaging in clinical oncology, especially in revolutionizing the safe and accurate delivery of state-of-the-art imaging-guided radiotherapy techniques. However, concerns are growing over the potential for sex-related bias and the omission of female-specific data in multi-organ segmentation algorithm development pipelines. Opportunities exist for addressing sex-specific data as a source of bias, and improving sex inclusion to adequately inform the development of AI-based technologies to ensure their fairness, generalizability and equitable distribution.
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