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Background: Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) is a rare leukemia subtype first classified by the World Health Organization in 2016. The incidence of Ph+ AML is approximately 0.5 - 3%, and its prognosis is poor.
View Article and Find Full Text PDF[Detection of BCR/ABL Fusion Gene and ASS1 Gene Deletion by Using Tricolor Dual-fusion Probe].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2020
Department of Hematology, Peking University Third Hospital, Beijing 100191,China,E-mail:
Article Synopsis
- The study aims to analyze abnormal signal patterns in Chronic Myeloid Leukemia (CML) and B-cell Acute Lymphoblastic Leukemia (B-ALL) patients using a specialized FISH probe to identify BCR/ABL fusion genes and ASS1 gene deletions.
- A total of 100 newly diagnosed patients were tested, revealing a high prevalence of the BCR/ABL fusion gene in CML (100%) and variable findings in B-ALL cases (32%).
- The findings suggest that the tricolor dual-fusion FISH probe is effective for detecting genetic abnormalities associated with these types of leukemia, which could aid in diagnosis and treatment planning.*
[Cytogenetic analysis of 362 cases of chronic myeloid leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2009
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province People Hospital, Nanjing 210029, China.
In order to evaluate the cytogenetic features and clinical significance of chronic myeloid leukemia (CML), chromosome preparation of bone marrow cells was made by using 24-hour culture, and R-banding technique was employed for karyotyping in 362 patients with CML. The patients were divided into two groups of chronic phase (CP) and blast crisis (BC). The results showed that the incidence of additional chromosome, variant translocation and Philadelphia (Ph) negative, bcr/abl positive CML with abnormal chromosomes in CP group were 70 cases (26.
View Article and Find Full Text PDF[Cytogenetic analysis on 135 cases of chronic myelogenous leukemias with non-simple Philadelphia chromosome].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2008
Dpartment of Hematology, The Hospital of Guilin Medical College, Guilin 541001, Guangxi Province, China.
The purpose of this study was to investigate 135 cases of chronic myelogenous leukemia with non-simple Philadelphia chromosome and to analyze their cytogenetic date. Chromosome preparations in 135 cases of patients were performed by using direct method and/or short-term culture, and karyotyping was performed with R-banding technique. The results showed that the overall frequency of chronic myelogenous leukemia with non-simple Philadelphia chromosome (based on 1210 cases of chromosome detection in chronic myelogenous leukemia) was 11.
View Article and Find Full Text PDFAn extended river buffalo (Bubalus bubalis, 2n = 50) cytogenetic map: assignment of 68 autosomal loci by FISH-mapping and R-banding and comparison with human chromosomes.
Chromosome Res
February 2009
National Research Council, Laboratory of Animal Cytogenetics and Gene Mapping, Via Argine 1085, 80147, Naples, Italy.
We report an extended river buffalo (Bubalus bubalis, 2n = 50; BBU) cytogenetic map including 388 loci, of which 68 have been FISH-mapped on autosomes in the present study. Ovine and caprine BAC clones containing both type I loci (known genes) and type II loci (simple sequence repeats (SRs), microsatellite marker, sequence-tagged sites (STSs)), previously assigned to sheep chromosomes, have been localized on R-banded river buffalo chromosomes (BBU), which expands the cytogenetic map of this important domestic species and increases our knowledge of the physical organization of its genome. The loci mapped in the present study correspond to loci already localized on homoeologous cattle (and sheep) chromosomes and chromosome bands, further confirming the high degree of chromosome homoeologies among bovids.
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