T cell activation mechanisms in the spleen induced by pertussis toxin (PT) were investigated. The degree of T cell activation was judged from results of helper activity assessed by measuring the in vitro antitrinitrophenyl (TNP) IgM antibody response. When mice were injected intraperitoneally with 4 X 10(5) sheep erythrocytes (SRBC) and concomitantly given an intravenous injection with 10 micrograms of PT 4 days previously, significant generation of nonspecific helper T cells was observed unless primed T cells were stimulated in vitro with TNP-SRBC. Stimulation with TNP-SRBC resulted in marked suppression of helper activity because it induced generation of suppressor T cells specific for the carrier antigen.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000233603 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.
Pain
December 2024
Palo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Previous preclinical and translational studies suggest that tissue trauma related to bony fracture and intervertebral disk disruption initiates the formation of pronociceptive antibodies that support chronic musculoskeletal pain conditions. This study tested this hypothesis in the monosodium iodoacetate (MIA) mouse model of osteoarthritis (OA) and extended the findings using OA patient samples. Monosodium iodoacetate was injected unilaterally into the knees of male and female wild-type (WT) and muMT mice (lacking B cells) to induce articular cartilage damage.
View Article and Find Full Text PDFMolecular Assay Versus Serology for Diagnosis of Scrub Typhus Among Patients With Acute Febrile Illness: A Retrospective Study.
Cureus
December 2024
Microbiology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Background And Objectives: The epidemiology of scrub typhus caused by has been growing in Odisha, India. The most common symptoms include fever, cough, lymphadenopathy, eschar, and rash. In India, enzyme-linked immunosorbent assays (ELISA) and DNA real-time polymerase chain reaction (DNA RT-PCR) are the most commonly used methods to diagnose scrub typhus.
View Article and Find Full Text PDFA customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases.
Sci Rep
January 2025
Vibrant Sciences LLC., San Carlos, CA, USA.
Tick-borne infections are the most common vector-borne diseases in the USA. Ticks harbor and transmit several infections with Lyme disease being the most common tickborne infection in the US and Europe. Lack of awareness about tick populations, specific diagnostic tests, and overlapping signs and symptoms of tick-borne infections can often lead to misdiagnosis affecting treatment and the prevalence data reported especially for non-Lyme tick-borne infections.
View Article and Find Full Text PDFBackground And Aims: Dengue is a mosquito-borne viral disease that frequently causes seasonal outbreaks in Bangladesh, particularly during the monsoon months from June to September. Recent outbreaks have shown significant shifts in clinical manifestations, including changes in the timeframe and serotype mixing. This study focused on the clinical and hematological profiles of patients during the 2022 outbreak, which was notably severe.
View Article and Find Full Text PDFPerformance of Antibody-Detection Tests for Human Melioidosis: A Systematic Review and Meta-analysis.
Malays J Med Sci
December 2024
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kelantan, Malaysia.
Melioidosis is a life-threatening infectious disease caused by the bacterium . Although culture is the gold standard for diagnosing melioidosis, it is time-consuming and delays timely treatment. Non-culture-based diagnostic techniques are interesting alternatives for the rapid detection of melioidosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!