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Characterization of NK Cells Using Single-Cell RNA Sequencing in Patients With Acute-On-Chronic Liver Failure.
J Gastroenterol Hepatol
January 2025
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background And Aim: Acute-on-chronic liver failure (ACLF) is characterized by fast progression and high mortality, with systemic inflammation and immune paralysis as its key events. While natural killer (NK) cells are key innate immune cells, their unique function and subpopulation heterogeneity in ACLF have not been fully elucidated. This study aimed to investigate the characteristics of NK cell subsets in the peripheral blood of patients with ACLF and determine their roles in the inflammatory responses.
View Article and Find Full Text PDFNature killer cell for solid tumors: Current obstacles and prospective remedies in NK cell therapy and beyond.
Crit Rev Oncol Hematol
January 2025
Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China. Electronic address:
In recent years, cell therapy has emerged as an innovative treatment method for the management of clinical tumors following immunotherapy. Among them, Natural killer (NK) cell therapy has achieved a significant breakthrough in the treatment of hematological tumors. However, the therapeutic effectiveness of NK cells in the treatment of solid tumors remains challenging.
View Article and Find Full Text PDFChanges in the cytotoxic and regulatory functions of NK cells in patients with long-COVID under the influence of the human herpesvirus 6 (pilot study).
Rheumatol Int
December 2024
Department of Clinical Immunology and Allergology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Article Synopsis
- Long-COVID patients often develop autoimmune disorders, possibly due to reactivation of dormant herpesvirus infections post-COVID-19, which disrupts immune system regulation.
- The study focused on analyzing specific markers on NK cells in 124 long-COVID patients based on the severity of their COVID-19 symptoms and the presence of HHV-6 reactivation.
- Results indicated imbalances in immune response mechanisms, with those who had severe COVID and HHV-6 reactivation showing increased levels of FasL and CD38, suggesting a risk for autoimmunity and impaired immune tolerance.
Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells.
Pathog Immun
April 2024
Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California.
Background: Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models. Furthermore, administration of natural killer (NK) cells following LRA treatment improves this reservoir reduction. It is currently unknown why the combination of a PKC modulator and NK cells is so potent and whether exposure to PKC modulators may augment NK cell function in some way.
View Article and Find Full Text PDFImage-based assessment of natural killer cell activity against glioblastoma stem cells.
FEBS Open Bio
June 2024
Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA.
Article Synopsis
- - Glioblastoma (GBM) is the most aggressive brain cancer, largely driven by glioblastoma stem cells (GSCs) which contribute to its recurrence and make treatment difficult.
- - Natural killer (NK) cells have potential against GSCs but struggle with effectiveness in the GBM environment due to limited infiltration.
- - This study presents new image-based assays to evaluate NK cell movement and ability to kill GSCs, aiming to enhance NK cell immunotherapy for better GBM management.
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