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A data-driven framework for developing a unified density-modulus relationship for the human lumbar vertebral body.
J Mech Behav Biomed Mater
January 2025
Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA; Center for Multiscale and Translational Mechanobiology, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Despite the broad agreement that bone stiffness is heavily dependent on the underlying bone density, there is no consensus on a unified relationship that applies to both cancellous and cortical compartments. Bone from the two compartments is generally assessed separately, and few mechanical test data are available for samples from the transitional regions between them. In this study, we present a data-driven framework integrating experimental testing and numerical modeling of the human lumbar vertebra through an energy balance criterion, to develop a unified density-modulus relationship across the entire vertebral body, without the necessity of differentiation between trabecular and cortical regions.
View Article and Find Full Text PDFBonding Features of Period 3 and Period 1 Two-Dimensional Superatoms.
J Phys Chem Lett
January 2025
Department of Chemistry, Anhui University, Hefei 230601, P. R. China.
Despite being studied for almost two centuries, aromaticity has always been a controversial concept. We previously proposed a unified aromatic rule for π-conjugated systems by two-dimensional (2D) superatomic-molecule theory, where benzenoid rings are treated as period 2 2D superatoms (3π-N, 4π-O, 5π-F, 6π-Ne) and, further, bond to form 2D superatomic molecules. Herein, to build a 2D periodic table, we further extend the theory to period 3 (7π-P, 8π-S, 9π-Cl, 10π-Ar) and period 1 (1π-H, 2π-He) elements.
View Article and Find Full Text PDFNumerical dynamics and optimal control for multi-strain age-structured epidemic model.
J Math Biol
January 2025
College of Mathematical Sciences, Harbin Engineering University, Harbin, China.
In this paper, a novel age-structured epidemiological model that simultaneously considers multiple viral strains is proposed. We develop a numerical framework for the study of the dynamics and optimal control by a linearly implicit Euler method, in which the biological meaning is unconditionally preserved. The first order convergence of numerical solutions in a finite time is derived from a uniform numerical boundedness.
View Article and Find Full Text PDFIn Silico Evaluation of Algorithm-Based Clinical Decision Support Systems: Protocol for a Scoping Review.
JMIR Res Protoc
January 2025
Health Services Research Centre, Singapore Health Services Pte Ltd, Singapore, Singapore.
Background: Integrating algorithm-based clinical decision support (CDS) systems poses significant challenges in evaluating their actual clinical value. Such CDS systems are traditionally assessed via controlled but resource-intensive clinical trials.
Objective: This paper presents a review protocol for preimplementation in silico evaluation methods to enable broadened impact analysis under simulated environments before clinical trials.
Understanding broader community perspectives on the scientific accuracy and stigma of personality trait labels.
Personal Disord
January 2025
Department of Psychology, Colorado State University.
Many labels are used within and across subfields to describe personality disorder (PD) and interpersonally-oriented trait dimensions. For example, "interpersonal disorders" is a suggested alternative label to "personality disorders" in clinical research. Other "dark trait" terms, though not proposed as formal labels for PDs, also are used in different research areas for describing externalizing traits.
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