Using an immune system isolated from a defined NANB epidemy we could find such markers in 29 of 71 patients (41%). The greater number of the antigen speaks in favour of a large pool of healthy carriers. The small number of patients with antibodies may be explained by the low sensibility of our test which detects only antibodies with high titers. According to this analysis of NANB associated immune markers the clinical importance of this infection in haemophiliacs seems to be small. Statements concerning the chronicity of the disease can not yet be made because of the preliminary character of this random test made in a holiday camp of haemophiliac children.
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Orv Hetil
September 2010
Semmelweis Egyetem, Altalános Orvostudományi Kar, I. Belgyógyászati Klinika, Budapest.
It is evidenced that both HBV and HCV infections may cause chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). HCV is considered as an oncogen virus. The mechanism of carcinogenesis in case of the two distinct viruses shows a number of common and different features.
View Article and Find Full Text PDFLiver Int
January 2009
National Institute of Diabetes and Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
In the late 1960's, only types A and B hepatitis were believed to exist, distinguished by circumstances of exposure and incubation periods. In the early 1970's, studies of transfusion recipients were begun with the belief that hepatitis B would be responsible should transfusion-associated hepatitis develop. After discovery of the viruses of hepatitis A and B, neither agent was found responsible, hence non-A, non-B (NANB) hepatitis.
View Article and Find Full Text PDFMinerva Gastroenterol Dietol
December 2000
National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
The entity of non-A, non-B (NANB) hepatitis was identified in the early 1970's in the course of studies of transfusion-associated hepatitis. It was first thought to be a mild illness because most persons identified with acute hepatitis lacked symptoms, had mild enzyme elevations, and were not jaundiced. It was only after realisation that enzyme elevations persisted in almost all affected persons, and that about 20% of those undergoing liver biopsy showed fibrosis and even cirrhosis, that concern began to grow.
View Article and Find Full Text PDFJ Gastroenterol Hepatol
April 2005
Gastroenterology Unit and Liver Transplant Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Background: For the majority of cases of acute liver failure in western Europe and North America an etiology cannot be defined. The condition is most often called fulminant non-A, non-B (NANB) hepatitis. Features such as female preponderance and presence of serum autoantibodies suggest a possible autoimmune basis.
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