Iontophoresis of histamine in the skin has been shown to release prostaglandins and arachidonic acid in suction blister fluid. Application of DMSO had a similar effect. No effect was found after using the following erythema and oedema irritants: scraping, vibration and ketocaine. Treatment with vasoconstricting drugs such as noradrenaline betamethasone and lidocaine-prilocaine mixture did not influence the prostaglandin or arachidonic acid levels.
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