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Extramedullary Hematopoiesis in Serous Cavity Fluids: A Closer Look at This Rare Phenomenon With Diagnostic Pitfalls and Prognostic Significance.
Diagn Cytopathol
December 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background: Extramedullary hematopoiesis (EMH) is usually seen in the reticuloendothelial system such as the spleen and liver; however, there have been rare case reports when EMH is seen in serous fluids (SFs). The aim of this study included analyzing the cytomorphological features of EMH in SFs in correlation with various clinicopathologic parameters and recognizing potential diagnostic pitfalls as well as their prognostic significance.
Methods: Clinicopathologic parameters and radiologic and pathologic information from the patients with a cytologic diagnosis of EMH were evaluated with cytology slides.
Metastatic germ cell tumors in serous cavities and cerebrospinal fluid: A single-center experience.
Cancer Cytopathol
September 2024
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Article Synopsis
- Metastatic germ cell tumors (GCTs) are rare and often found in body cavities like serous fluids and cerebrospinal fluid (CSF), making diagnosis difficult due to limited existing literature.
- A study from 1990 to 2024 identified 27 cases of GCTs, primarily originating from the testis and ovaries, with a significant portion having mixed tumor types and a median time of 7 months between initial diagnosis and detection of malignant fluid.
- The prognosis for patients with metastatic GCTs in body cavities is generally poor, with nearly half of the patients succumbing to the disease and most showing metastases to other sites; however, effective subtyping can
Diagnostic significance of cerebrospinal fluid flow cytometry in Chinese children with B lineage acute lymphoblastic leukemia.
BMC Pediatr
March 2024
Department of Hematology and Oncology, Shenzhen Children's Hospital, No.7019 Yitian Road, Futian District, Shenzhen, China.
Article Synopsis
- Central nervous system leukemia (CNSL) is a serious complication in childhood leukemia, and this study compares the diagnostic effectiveness of cytomorphology (CM) and flow cytometry (FCM) in detecting it.
- The research involved 165 children with B-cell Acute Lymphoblastic Leukemia, assessing cerebrospinal fluid (CSF) samples through routine analysis, CM, and FCM, along with imaging techniques.
- Results showed that FCM was more sensitive than CM for diagnosing CNSL, highlighting the need for a combined approach of CM, FCM, and imaging to better detect CNSL and improve event-free survival rates in childhood leukemia.
Silica and barium: Comparison of microscopic appearance and characterization of effects of silica on cytomorphology.
Vet Clin Pathol
December 2023
Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Background: Silica from plastic red top sample collection tubes and barium cause recognized artifacts in slide preparations for microscopic examination.
Objectives: The objectives of this study were to evaluate and directly compare the microscopic appearance of silica and barium particles and various slide preparation techniques (e.g.
Diagnostic Value and Prognosis Significance of Cerebrospinal Fluid Examination by Flow Cytometry in Pediatric Acute Lymphoblastic Leukemia.
Technol Cancer Res Treat
June 2023
Pediatric Department, The People's Hospital of Peking University, Beijing, China.
Article Synopsis
- The study investigates the use of flow cytometry (FC) in examining cerebrospinal fluid (CSF) to diagnose and understand the prognosis of central nervous system leukemia (CNSL) in pediatric patients with newly diagnosed acute lymphoblastic leukemia.
- Among 986 patients, FC identified CNSL in 31 cases (3.14% positive rate), while a cytomorphology test detected only 6 cases (0.61% positive rate), suggesting FC combined with cytomorphology enhances diagnostic sensitivity.
- The two-year event-free survival (EFS) and overall survival (OS) rates were significantly lower for patients who tested positive by FC compared to those who tested negative, indicating a worse prognosis, although E
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