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[A case of synchronous mediastinal and pineal germ cell tumors].
Zhonghua Er Ke Za Zhi
January 2025
Department of Medical Oncology, Pediatric Oncology Center,Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, National Key Clinical Discipline of Pediatric Oncology,Laboratory for Clinical Medicine, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing100045, China.
[Cytological diagnosis of 3 cases of primary mediastinal yolk sac tumor with pleural effusion].
Zhonghua Bing Li Xue Za Zhi
June 2024
Department of Pathology, Jiangsu Province Hospital (the First Affiliated Hospital of Nanjing Medical University), Nanjing 210029, China.
A 25-year-old male received palliative total gastrectomy plus D1 dissection plus Roux-en-Y reconstruction for hemorrhagic gastric cancer with left Virchow lymph node metastasis in 2013. The final diagnosis was Type 2, pT4a(se), pap>tub2 >hepatoid adenocarcinoma, pN3b, sM1, fStage Ⅳ. Because AFP was as high as 11,000 ng/mL, he was diagnosed with AFP-producing gastric cancer and started S-1 plus CDDP therapy.
View Article and Find Full Text PDFTesticular cancer: new developments, molecular pathology, and current research keynote.
Pathologie (Heidelb)
December 2023
Department of Morphological Sciences, Cordoba University Medical School, Avda. Menendez-Pidal S/N, 14004, Cordoba, Spain.
Germ cell tumors (GCTs) are now considered a curable cancer, with a > 95% cure rate in all patients and about 90% cure rate in patients with metastatic disease. The success of physicians in curing the disease is underpinned by multidisciplinary advances. Of relevance in this regard are the nowadays-applied homogeneous terminology based on pathologically better characterized testicular neoplasms and the development of a widely used risk stratification model for metastatic disease introduced by the International Germ Cell Cancer Collaborative Group in 1997 and updated in 2021.
View Article and Find Full Text PDF[F]fluorodeoxyglucose positron emission tomography/computed tomography characteristics of primary mediastinal germ cell tumors.
Sci Rep
October 2023
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- Primary mediastinal germ cell tumors (MGCTs) are rare tumors that have a worse prognosis compared to gonadal germ cell tumors; a study analyzed 35 MGCT patients using [F]FDG PET/CT for better understanding.
- Visual assessment found that uptake intensity was a significant factor in distinguishing benign from malignant MGCTs, while quantitative analysis revealed that SUVmax and other parameters were significantly higher in malignant cases.
- The SUVmax showed strong predictive ability in differentiating tumor types and correlating with serum alpha-fetoprotein (AFP) levels, indicating its potential as a diagnostic tool for MGCTs.
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