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mRNA vaccines in the context of cancer treatment: from concept to application.
J Transl Med
January 2025
Department of Biochemistry and Molecular Biology, Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, P. R. China.
Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeutic management of malignant diseases, primarily due to their impressive impact on the COVID-19 pandemic. In this comprehensive review, we offer a systematic overview of mRNA vaccines, focusing on the optimization of structural design, the crucial role of delivery materials, and the administration route.
View Article and Find Full Text PDFThe Art of Clinical Negotiation.
J Allergy Clin Immunol Pract
January 2025
Dartmouth Hitchcock Medical Center, Section of Allergy and Clinical Immunology, Lebanon, NH; Geisel School of Medicine at Dartmouth, Departments of Medicine and Pediatrics. Electronic address:
The art of clinical negotiation is an important, yet underappreciated aspect of medicine. Key components of negotiation include the need to consider principles over personalities, to explore all options before deciding on the best course, to realize if consensus cannot be achieved then compromise may still be possible, to work from evidence to incorporate contextual factors, and to stay evidence based. These principles can be helpful in many settings, including contract negotiation, drug pricing, and research.
View Article and Find Full Text PDFExploring the Therapeutic Potentials and Molecular Mechanisms of Alkaloids in Ulcerative Colitis: An Integrative Network Pharmacology and Molecular Docking Approach.
Prev Nutr Food Sci
December 2024
School of Food Science & Biotechnology, Kyungpook National University, Daegu 41566, Korea.
, a medicinal plant traditionally used in Southeast Asia, exerts protective effects against various inflammatory diseases, primarily due to its rich alkaloid content. Despite substantial evidence supporting its anti-inflammatory properties, the biological activities of are unclear. This study aimed to elucidate anticolitis mechanisms of alkaloids (CFAs) using an integrative approach of network pharmacology and molecular docking analyses.
View Article and Find Full Text PDFA comprehensive overview of tolerogenic vaccine adjuvants and their modes of action.
Front Immunol
January 2025
Amgen Research, Amgen Inc., South San Francisco, CA, United States.
Tolerogenic vaccines represent a therapeutic approach to induce antigen-specific immune tolerance to disease-relevant antigens. As general immunosuppression comes with significant side effects, including heightened risk of infections and reduced anti-tumor immunity, antigen-specific tolerance by vaccination would be game changing in the treatment of immunological conditions such as autoimmunity, anti-drug antibody responses, transplantation rejection, and hypersensitivity. Tolerogenic vaccines induce antigen-specific tolerance by promoting tolerogenic antigen presenting cells, regulatory T cells, and regulatory B cells, or by suppressing or depleting antigen-specific pathogenic T and B cells.
View Article and Find Full Text PDFDengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis.
Open Forum Infect Dis
January 2025
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Background: Dengue virus (DENV) is an arboviral pathogen found in >100 countries and a source of significant morbidity and mortality. While the mechanisms underpinning the pathophysiology of severe Dengue are incompletely understood, it has been hypothesized that antibodies directed against the DENV envelope (E) protein can facilitate antibody-dependent enhancement (ADE) of the infection, increasing the number of infected cells and the severity of disease in an exposed individual. Accordingly, there is interest in defining mechanisms for directly targeting DENV-infected cells for immunologic clearance, an approach that bypasses the risk of ADE.
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