The diagnostic possibility of hypertonic Oddi's sphincter dysfunction was evaluated in 100 cholecystectomized and 28 noncholecystectomized patients. An organic lesion interfering with free bile flow was ruled out in every case. The existence of the syndrome, i.e., the dysfunction of the Oddi's musculature, was verified using the morphine-choleretic test combined with either dynamic hepatobiliary scintigraphy or (in selected cases) percutaneous transhepatic cholangiography. Hypertonic Oddi's sphincter dyskinesia can be regarded as an independent clinical syndrome.
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Aim: To study function of the liver, sphincter system and the gall bladder (GB) in patients with biliary dyskinesia (BD).
Material And Methods: Thirty-four patients with BD have undergone clinical, fibrogastroduodenoscopic examinations, fractional duodenal intubation with examination of the bile, ultrasonography, dynamic scintigraphy of the hepatobiliary system.
Results: The examination of the patients has detected GB hypotonia (65%), GB hypertension (35%), Oddi's sphincter hypertention (28%), Oddi's sphincter hypotonia (44%), Lutkens' sphincter hypertonicity (19%), Lutkens' sphincter hypotonia (13%), impairment of intrahepatic biliary tracts (65%), lithogenic bile (100%), duodenogastric reflux (41%).
Aim: To characterize motor-kinetic and inflammatory changes in extrahepatic biliary tracts and gallbladder in patients with chronic viral hepatitis (CVH). To ascertain whether there is a pathogenetic correlation between affection of the biliary system and viral infection.
Material And Methods: The condition of the biliary tract was examined in 183 patients with CVH using fractionated duodenal tubing with biochemical tests and bacteriological investigation of bile, dynamic ultrasonic investigation.
Our study has shown the clinical significance of treating of a gall-bladder hypomotor dyskinesia and hypertone of the Oddi's sphincter. Hypomotor dysfunction of gall bladder occurs in 24% patients with cholelithiasis and after a remote lithotripsy in 62.5%, 50% of patients with stenosis of Oddi's sphincter have microcholelithiasis (MCL) and 100% of patients have "sludge".
View Article and Find Full Text PDF[The effect of theophylline preparations on morphine-induced spasm of Oddi's sphincter in man].
Orv Hetil
June 1998
Szent Imre Kórház, Budapest, II. Belgyógyászati Osztály.
In this paper a short overview is given about pathophysiology of Oddi's sphincter function and diagnosis as well as pharmacological therapy of the hypertonic dyskinesia. According to the pharmacological background of muscle relaxation in other organs, theophyllin preparations: aminophyllin and retard theophyllin were used to inhibit spasm of Oddi's sphincter provoked by morphine in 9 patients with hypertonic dyskinesia of biliary and/or pancreatic outlet. The enzyme elevations (SGOT and/or amylase) and pain response to morphine significantly diminished in all but one patient during the evocative tests and the effect seemed to be dose-dependent until about 500 mg of theophyllin.
View Article and Find Full Text PDF[Endoscopic manometry of Oddi's sphincter].
Rev Med Chil
November 1997
Departamento de Medicina, Hospital Clínico de la Universidad de Chile, Santiago, Chile.
Background: Endoscopic manometry is the gold standard for the diagnosis of sphincter of Oddi dysfunction.
Aim: To report the results of the first 30 endoscopic manometries of sphincter of Oddi performed in a Gastroenterology Service.
Patients And Methods: Thirty manometries were performed in 28 patients aged 30 to 70 years old (14 females).
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