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Antihypertensive, Anti-Inflammatory, and Antiangiogenic In Silico Activity of Lactoferrin-Derived Peptides of Equine Milk Hydrolysate.
Biomedicines
November 2024
Department of Biotechnology, Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi 71, Almaty 050040, Kazakhstan.
Background: Equine milk, including its whey proteins, is a source of nutrients and functional components in the human diet, and is especially beneficial for people with weakened immune systems, newborns, and athletes. Objectives Whey proteins in equine milk constitute approximately 20% of the total protein content and include various fractions such as albumin, globulin, and lactoferrin. Lactoferrin is one of the most extensively studied whey proteins in equine milk.
View Article and Find Full Text PDFCopper-Chelated Chitosan Microgels for the Selective Enrichment of Small Cationic Peptides.
Gels
April 2024
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, D04 V1W8 Dublin, Ireland.
Article Synopsis
- Copper-chelated chitosan microgels are used as a new method for separating peptides through immobilized metal affinity chromatography (IMAC), showing strong interactions with various amino acids.
- The microgels specifically capture anionic amino acids, leading to a relative increase in cationic amino acids in the solution.
- Testing on milk hydrolysates revealed that these beads effectively removed larger peptides, enriching the solution in smaller cationic peptides known for beneficial bioactivities like anti-microbial effects.
An Efficient Peptidomics Screening for Exogenous Substrates and Inhibitory Peptides of the Dipeptidase ACE from Milk Hydrolysate.
Pharmaceutics
January 2023
Department of Biological Science and Technology, National Pingtung University of Science and Technology, 1 Shuefu Road, Neipu, Pingtung 91201, Taiwan.
The dipeptidase angiotensin-I-converting enzyme (ACE) pre-incubation, liquid chromatography- mass spectrometry (LC-MS), and stable-isotope labeling were integrated for an efficient screening of ACE's exogenous substrates from milk hydrolysate. Using this approach, 31 substrates were readily identified from 478 identified peptides and their activities were confirmed using synthetic peptides. Their reactivity is highly correlated with the decreased isotope ratio observed in LC-MS.
View Article and Find Full Text PDFThe Novel Peptide Chm-273s Has Therapeutic Potential for Metabolic Disorders: Evidence from In Vitro Studies and High-Sucrose Diet and High-Fat Diet Rodent Models.
Pharmaceutics
September 2022
Metabico Inc., Newton, MA 02460, USA.
The aim of this study was to develop a novel peptide potentially applicable for the treatment of metabolic conditions, such as obesity and type 2 diabetes (T2D). We identified CHM-273S from the list of peptides from milk hydrolysate obtained by HPLC/MS-MS. In vitro analysis of primary murine fibroblasts indicated the potential of CHM-273S to upregulate IRS2 mRNA expression.
View Article and Find Full Text PDFEffect of milk protein hydrolysate supplementation on protein energy malnutrition-induced gut dysbiosis.
Food Funct
October 2022
Protein Chemistry and Technology Department, CSIR-Central Food Technological Research Institute, Mysore-570020, India.
Dairy proteins in the diet are beneficial for the growth of probiotics; however, what is unknown is the gut-mediated immune responses under protein energy malnutrition (PEM) and if dairy protein hydrolysates can be effective as dietary interventions. This study compares the composition of the gut microbiota of rats with moderate protein deficiency (M.PEM) and severe protein deficiency (S.
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