Richter's syndrome is characterized by the association of malignant lymphoma with chronic lymphatic leukemia. Three new cases of this syndrome are reported and compared with those previously reported in the world literature. The relationship between the two lymphoid neoplasms is discussed.
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Rev Med Interne
January 2025
Service de médecine interne, centre national de référence des syndromes drépanocytaires majeurs de l'adulte, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Inserm U1163, laboratoire « Mécanismes cellulaires et moléculaires des désordres hématologiques et implications thérapeutiques », institut Imagine, université Paris-Cité, 75015 Paris, France; Laboratoire d'Excellence GR-Ex, 75015 Paris, France; Faculté de santé, université Paris-Cité, 75006 Paris, France. Electronic address:
Introduction: Extramedullary hematopoiesis (EMH) is very rarely described during sickle cell disease (SCD). Our aim was to describe six cases of EMH occurring in adult SCD patients and to conduct a literature review.
Methods: Retrospective, descriptive, and monocentric study, identifying all cases of EMH recorded in our cohort of adult SCD patients, up to April 2024.
Rev Med Interne
December 2024
Service de médecine interne, CHI Poissy-St Germain, 10, rue du Champs Gaillard, 78300 Poissy, France.
Introduction: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic), recently described, due to a somatic mutation of the UBA1 gene and often associated with hemopathy, is characterized by systemic symptoms close to those described in Still's disease or relapsing polychondritis. There are also patients with hemopathy, presenting inflammatory symptoms reminiscent of those of VEXAS syndrome but without mutation of the UBA1 gene.
Case/discussion: Two male patients consulted for general signs, dermatological symptoms, arthralgia, chondritis and venous thrombosis, like patients in the French cohort suffering from VEXAS syndrome.
Pan Afr Med J
December 2024
Service d'Epidémiologie et Médecine Communautaire, Centre Hospitalier Universitaire Hedi Chaker de Sfax, Sfax, Tunisie.
The benefits of permanent cardiac pacing have been widely demonstrated. However, the literature on complications remains inconsistent. We lack precise information about the frequency of complications and their predictive factors in our center.
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November 2024
Faculté de Médecine et d'Odonto-Stomatologie (FMOS) / Université des sciences, des Techniques et des Technologies de Bamako, MALI.
Pan Afr Med J
November 2024
Service d'Otorhinolaryngologie et de Chirurgie Cervico-Faciale, Hôpital Universitaire International Cheikh Zaid, Université des Sciences de la Santé, Rabat, Maroc.
Extraskeletal Ewing's sarcoma is a malignant tumour most often found in children and adolescents, but rarely in the cervicofacial region. When it affects the parapharyngeal space, diagnosis is often delayed, resulting in poor prognosis. We here report the clinical case of a 37-year-old female patient admitted to the emergency department with inspiratory dyspnea, asthenia and anorexia.
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