AI Article Synopsis
- The study analyzed the antigenic properties of monoclonal IgM kappa components in three mixed IgM-IgG cryoglobulins using gel-diffusion precipitin analysis.
- An unusual determinant specific to the kappa-chain was found in the IgM components, which was absent in other studied monoclonal immunoglobulins and normal IgG.
- Antibodies against this unique determinant were identified in both anti-kappa and anti-lambda sera, as well as in sera targeting hidden determinants of L-chains.
Article Abstract
Antigenic features of monoclonal IgM kappa components of three mixed IgM-IgG cryoglobulins were studied by gel-diffusion precipitin analysis. An unusual kappa-chain determinant was revealed in the IgM components but not in other monoclonal immunoglobulins (IgM kappa, BJ kappa) or normal IgG. Antibodies to this determinant were found not only in anti-kappa, but also in anti-lambda sera, and in antisera to hidden determinants of L-chains.
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| http://dx.doi.org/10.1016/0165-2478(83)90014-7 | DOI Listing |
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