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Activity of BatIFIT5 in different species of healthy and naturally infected with rabies virus bats.
Vet Ital
July 2024
Instituto Pasteur, São Paulo, SP, Brazil; Universidade Federal do ABC (UFABC), Santo André, SP, Brazil.
Bats are mammals with vital role played in numerous ecosystem services, however bats can be important reservoirs or hosts for several microorganisms. Rabies is a zoonosis caused by Rabies lyssavirus (RABV) that affects the central nervous system (CNS) of all mammals, including bats and humans. The action of IFN-stimulated genes (ISGs) could be responsible for inhibiting different stages of the viral replication cycle.
View Article and Find Full Text PDFEvaluation of one year immunity following rabies post-exposure prophylaxis in dog bite cases.
NPJ Vaccines
November 2024
Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Rabies remains a global health threat despite being preventable with post-exposure prophylaxis (PEP). This study assessed one-year humoral and T cell immunity in PEP recipients of the Insitut Pasteur du Cambodge (IPC) regimen, recommended by WHO. We analyzed rabies virus (RABV) neutralizing antibodies (nAbs) and T cell responses at baseline, 7 and 14 days, 6 and 12 months after PEP.
View Article and Find Full Text PDFThe Immune Escape Strategy of Rabies Virus and Its Pathogenicity Mechanisms.
Viruses
November 2024
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530004, China.
In contrast to most other rhabdoviruses, which spread by insect vectors, the rabies virus (RABV) is a very unusual member of the Rhabdoviridae family, since it has evolved to be fully adapted to warm-blooded hosts and spread directly between them. There are differences in the immune responses to laboratory-attenuated RABV and wild-type rabies virus infections. Various investigations showed that whilst laboratory-attenuated RABV elicits an innate immune response, wild-type RABV evades detection.
View Article and Find Full Text PDFA Comprehensive Review on the Intricate Interplay between COVID-19 Immunization and the New Onset of Pemphigus Foliaceus.
Vaccines (Basel)
July 2024
Department of Oncologic Dermatology, "Elias" Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Autoimmune bullous diseases (AIBDs) are characterized by the formation of vesicles, bullous lesions, and mucosal erosions. The autoantibodies target the cellular anchoring structures from the surface of epidermal keratinocyte named desmosomes, leading to a loss of cellular cohesion named acantholysis. AIBDs are classified into intraepidermal or subepidermal types based on clinical features, histological characteristics, and immunofluorescence patterns.
View Article and Find Full Text PDFComparative analysis of rabies pathogenic and vaccine strains detection by RIG-I-like receptors.
Microbes Infect
May 2024
Institut Pasteur, Université Paris Cité, Lyssavirus Epidemiology and Neuropathology Unit, 75015 Paris, France. Electronic address:
Rabies virus (RABV) is a lethal neurotropic virus that causes 60,000 human deaths every year globally. RABV infection is characterized by the suppression of the interferon (IFN)-mediated antiviral response. However, molecular mechanisms leading to RABV sensing by RIG-I-like receptors (RLR) that initiates IFN signaling currently remain elusive.
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