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Integrated Proteomics and Machine Learning Approach Reveals PYCR1 as a Novel Biomarker to Predict Prognosis of Sinonasal Squamous Cell Carcinoma.
Int J Mol Sci
December 2024
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Mueang Khon Kaen, Khon Kaen 40002, Thailand.
Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with a high 5-year mortality rate. However, proteomic technologies have not yet been utilized to identify SNSCC-associated proteins, which could be used as biomarkers. In this study, we aimed to discover a biomarker to predict SNSCC patients using proteomic analysis integrated with machine learning models.
View Article and Find Full Text PDFClinical Presentation of Frontal Sinus Squamous Cell Carcinoma in the Dog and Response to Treatment With Radiation Therapy in Eight Dogs.
Vet Radiol Ultrasound
January 2025
OnkolVet Veterinary Clinic Opole and Poznan University of Life Science, Poznań, Poland.
Primary frontal sinus squamous cell carcinoma (PFSSCC) represents a rare disease in dogs, and there is a general paucity of information in the current veterinary literature regarding its presentation and response to radiation therapy. The objective of this retrospective observational study was to describe a series of dogs diagnosed with PFSSCC and report their response to radiation therapy. Medical records of dogs with a diagnosis of PFSSCC were reviewed.
View Article and Find Full Text PDFEpidemiological Features of Sinonasal Adenocarcinoma and Prognostic Nomogram: A Study Based on the SEER Database.
Cancer Control
January 2025
Department of Oncology, Suining Central Hospital, Suining, China.
Objective: Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, and devise a predictive nomogram for overall survival (OS).
Methods: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, cases of SNAC from 2000 to 2020 were analyzed for incidence trends. Univariate and multivariate Cox regression models helped pinpoint factors impacting patient survival.
Identification and validation of Novel Estrogen Biosynthesis Biomarkers in Sinonasal Inverted Papilloma.
Int J Med Sci
January 2025
Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
Article Synopsis
- Sinonasal inverted papilloma (SNIP) has a high recurrence rate and the potential to become malignant, but its specific metabolic pathways and biomarkers are not fully understood.
- RNA sequencing identified significant gene alterations related to the estrogen biosynthesis pathway and highlighted five key biomarkers (AKR1B10, CYP1B1, CYP2C19, CYP3A5, and HSD17B13) that were correlated with SNIP pathogenesis.
- Functional analysis indicated that these biomarkers are involved in epithelial cell proliferation and EGFR signaling regulation, suggesting their potential as diagnostic and therapeutic targets for managing SNIP.
Fibro-osseous lesions of the sinonasal tract: a contemporary review.
Curr Opin Otolaryngol Head Neck Surg
February 2025
Department of Otolaryngology - Head & Neck Surgery, University of Florida, Gainesville, Florida, USA.
Purpose Of Review: Fibro-osseous lesions (FOL) are benign, slow-growing lesions that are often incidentally discovered in the sinonasal cavity. They may necessitate surgical resection in patients with postobstructive sinusitis, or in cases of cranial nerve and orbital compression. We examine the recent advancements in otolaryngology relating to diagnostic characteristics and treatments for FOL, with emphasis on new technologies to improve outcomes and reduce recurrence.
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