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Emodin Enhanced Microwave-Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria-Infected Osteomyelitis.
Adv Sci (Weinh)
January 2025
Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, 030024, China.
Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves.
View Article and Find Full Text PDFThermally regulated flocculation-coalescence process by temperature-responsive cationic polymeric surfactant for enhanced crude oil-water separation.
J Hazard Mater
January 2025
Zhongyuan Critical Metals Laboratory, Zhengzhou University, Zhengzhou 450001, China; School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China; The Key Lab of Critical Metals Minerals Supernormal Enrichment and Extraction, Ministry of Education, Zhengzhou 450001, China. Electronic address:
Polymeric surfactants play a crucial role in the flocculation-assisted coalescence process due to their unique bridging effect. However, the steric hindrance induced by their large molecules severely impedes the coalescence of oil droplets. Herein, temperature-responsive polymeric surfactants (quaternary ammonium chitosan-g-PNIPAM, Q-g-PN) with thermally-modulated structure were designed by integrating thermal responsive moieties onto cationic chitosan.
View Article and Find Full Text PDFArticle Synopsis
- Cone dystrophy with supernormal rod response (CDSRR) is a rare genetic condition affecting the retina, characterized by weakened photoreceptor responses; the study looks at its clinical course and genetic mutations in children.* -
- Genetic testing using next-generation sequencing and other methods confirmed mutations in a specific gene related to a protein (Kv8.2) that affects ion channels in the retina.* -
- Clinical symptoms included hypermetropia and slight exotropia, with electroretinogram (ERG) tests showing distinctive patterns, such as increased b-wave latency, linked to the identified mutations.*
Establishment of a human induced pluripotent stem cell line (ABi004-A) carrying a compound heterozygous mutation in the KCNV2 gene.
Stem Cell Res
October 2024
Life Sciences Research Center, Moscow Institute of Physics and Technology, National Research University, Dolgoprudny, Russia; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
Pathogenic variants in the KCNV2 gene can cause a rare retinal dystrophy that can be inherited recessively, known as cone dystrophy with supernormal rod response (CDSRR). CDSRR leads to specific changes in photoreceptors' electroretinogram response, especially in the rods, poor visual acuity, photophobia, and even maculopathy. The derived iPSC lines from patients with CDSRR may pave the way for apprehension of the pathogenetic mechanism and drug development using in vitro models.
View Article and Find Full Text PDFClinical course of two siblings with potassium voltage-gated channel modifier subfamily V member 2 (KCNV2)-associated retinopathy.
Doc Ophthalmol
June 2024
Department of Ophthalmology, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan.
Background: KCNV2-associated retinopathy causes a phenotype reported as "cone dystrophy with nyctalopia and supernormal rod responses (CDSRR; OMIM# 610356)," featuring pathognomonic findings on electroretinography (ERG). Here, we report the clinical courses of two siblings with CDSRR.
Case Reports: Patient 1: A 3-year-old boy with intermittent exophoria was referred to our hospital.
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