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My beloved husband, Robert Steel, died at 58 from MAPT FTD, a disease that stretches back through his family's generations. Before we married he told me his father died of early-onset Alzheimers and he was terrified he would inherit that disease. In his early 50s he began exhihibiting symptoms that I attributed to stress-his work as a respected high school teacher began to slip, he began to lose the ability to have a visual map in his head, he began to repeat stories, his behavior became more compulsive, forgot how he was related to a favorite cousin.
View Article and Find Full Text PDFInternational Consensus Guidance for the Management of Glucocorticoid Related Complications in Neuromuscular Disease.
Muscle Nerve
January 2025
Neurology Quality and Innovation Lab, Division of Neurology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Introduction/aims: Glucocorticoid (GC)-related adverse reactions and risks are commonly seen during the treatment of immune-mediated and inflammatory neuromuscular disorders. There is wide variation in the management of associated complications. The aim of this study is to develop international consensus guidance on the management of GC-related complications in neuromuscular disorders.
View Article and Find Full Text PDFCost-Effective Drug Testing: Analytical Methodology, Best Practices, and Clinical Utility.
J Appl Lab Med
January 2025
Department of Pathology and Laboratory Medicine, UC Davis Health, Sacramento, CA, United States.
Background: Drug overdose-related deaths continue to increase globally. Testing demands have likewise increased, prompting healthcare facilities to adopt a range of methods, from simple point-of-care immunoassays to comprehensive chromatographic and mass spectrometry-based techniques. Each of these testing methods has trade-offs related to cost, performance, speed, and convenience, requiring healthcare facilities to carefully determine the best options to meet their clinical needs.
View Article and Find Full Text PDFEvaluation Checklist for the Multidisciplinary Approach to Patients with Asthma or Suspected Asthma in United Airway Disease.
J Asthma Allergy
December 2024
Department of Allergology, Hospital Universitario La Paz, Madrid, Spain.
Purpose: To generate an evaluation checklist for the multidisciplinary approach to patients with asthma or suspected asthma.
Patients And Methods: This was a qualitative study based on a literature review and expert opinions. A multidisciplinary steering committee with knowledge and experience in asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) was established and comprised two pneumologists, two allergologists, and two otorhinolaryngologists.
Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon.
Front Genet
December 2024
Instituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru.
Introduction: Malaria molecular surveillance (MMS) can provide insights into transmission dynamics, guiding national control programs. We previously designed AmpliSeq assays for MMS, which include different traits of interest (resistance markers and deletions), and SNP barcodes to provide population genetics estimates of and parasites in the Peruvian Amazon. The present study compares the genetic resolution of the barcodes in the AmpliSeq assays with widely used microsatellite (MS) panels to investigate population genetics of Amazonian malaria parasites.
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