The aim of this study was to investigate the effect of cortisone on the behavior of serotonin metabolism indicators in experiments carried out in rabbits. The following parameters were determined: the level of serotonin (5-hydroxy-tryptamine), (5-HT) in liver tissue and blood, the activity of monoamino-oxidase (MAO) in liver tissue and serum, and the level of 5-hydroxy-indoloacetic acid (5-HIAA) in liver tissue and in 24-hour urine of 52 rabbits. The experimental model involved acute liver injury with carbon tetrachloride--CCl4 and the effect of exogenous cortisone on the behavior of the above-mentioned indicators. On the basis of the experimental findings the authors demonstrate a dependence of serotonin metabolism on the liver injury, and an absence of normalization of the estimated parameters after cortisone administration.
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