AI Article Synopsis
- Thirty-three patients with advanced cervical cancer, largely squamous type, were treated with a combination of bleomycin and mitomycin C after prior radiotherapy.
- The treatment resulted in a 36% objective response rate, including five complete remissions and seven partial remissions, but also led to severe side effects like myelosuppression and pulmonary fibrosis.
- Overall, while the regimen showed some effectiveness, its impact was limited, highlighting the need for further research in advanced cervical cancer treatments.
Article Abstract
Thirty-three patients with advanced cervical cancer (31 squamous cancer, two adenosquamous cancer) previously untreated with cytotoxic drugs, were treated with bleomycin, 5 mg daily, for seven days and mitomycin C, 10 mg, on day 8. This regimen was repeated four times at two-week intervals. All but one patient had previously been treated with radiotherapy; 36% of the patients had an objective response (five complete remission (CR), median duration 12 months; seven partial remission (PR), median duration six months). Severe myelosuppression occurred in nine patients. One drug-related death due to thrombocytopenia occurred. Three patients developed pulmonary fibrosis and one of them died of respiratory failure. The bleomycin-mitomycin C regimen has a definite but clearly limited effect in advanced cancer of the uterine cervix.
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| http://dx.doi.org/10.1002/1097-0142(19830215)51:4<591::aid-cncr2820510406>3.0.co;2-9 | DOI Listing |
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