[Dynamics of the formation of staphylococcal antigen-specific lymphocytes in the lymphoid organs of mice after subcutaneous and intravenous immunization].

The immunization of mice with heat-killed staphylococci made in a single subcutaneous injection does not induce any perceptible changes in the number of antigen-binding cells (ABC), specific to staphylococci, in the lymphoid organs and any increase in the titer of serum antibodies. As the result of immunization in a single intravenous injection, the number of ABC in the spleen rapidly increases, reaching its maximum in 4 days after immunization, and then gradually decreases, reaching the control level in 2 weeks. The occurrence of ABC in the marrow drops sharply during the first 2-4 days after immunization, then starts to rise slowly, reaching the initial level in 3-4 weeks. The single intravenous injection of staphylococci induces a rapid increase in the titer of antistaphylococcal serum IgM.