AI Article Synopsis
- Researchers studied the impact of beta-adrenergic stimulation on tracheal mast cell reactions in 12 anesthetized dogs.
- The control group showed significant histamine release from tracheal mast cells, correlating with contractions in the trachea.
- Injections of isoproterenol prior to a mast cell-stimulating compound inhibited both histamine release and tracheal contractions, suggesting that beta-adrenergic stimulation can prevent mast cell degranulation.
Article Abstract
In 12 anesthetized dogs, we tested the effects of pharmacologic beta-adrenergic stimulation on the severity of tracheal mast cell reactions in vivo (Am Rev Respir Dis 1979; 119:62). In control dogs, tracheal arterial injections of compound 48/80 produced arteriovenous differences in histamine concentrations across the trachea (35 +/- 15 ng/ml), but not the lung; this finding suggested selective degranulation of tracheal mast cells. Tracheal arteriovenous histamine differences correlated (r = 0.70) with tracheal contractions (12 +/- 4 g/cm) induced by compound 48/80 in these animals. In other dogs, injections of isoproterenol (10 micrograms/kg) before compound 48/80 prevented the development of both tracheal arteriovenous differences and contractions. We concluded that pharmacologic beta-adrenergic stimulation inhibited degranulation of tracheal mast cells. The preparation appears suitable for examining the effects of endogenous stimuli on the severity of mast cell reactions in the central airways of anesthetized dogs.
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| http://dx.doi.org/10.1164/arrd.1982.126.5.842 | DOI Listing |
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