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Comparative analysis of the interaction mechanism of γ-globulin and hemoglobin with spherical and rod-shaped gold nanoparticles.
Chem Biol Interact
November 2024
Grade 2019, Clinical Medicine, School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, PR China.
The interaction mechanism of spherical gold nanoparticles (AuNPs) and rod-shaped gold nanoparticles (AuNRs) with γ-globulin and hemoglobin was comprehensively and comparatively analyzed. γ-Globulin and hemoglobin have high affinity with AuNPs, and with two different types of binding sites on AuNRs surface. Except hemoglobin interaction with the first binding site of AuNRs, the interaction between γ-globulin/hemoglobin and AuNPs/AuNRs is the spontaneous, endothermic and entropy-driven process, and hydrophobic interaction plays a dominant role.
View Article and Find Full Text PDFKinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis.
J Chem Theory Comput
April 2024
School of Information Science & Engineering, Lanzhou University, South Tianshui Road, Lanzhou 730000, Gansu, China.
The ordered assembly of Tau protein into filaments characterizes Alzheimer's and other neurodegenerative diseases, and thus, stabilization of Tau protein is a promising avenue for tauopathies therapy. To dissect the underlying aggregation mechanisms on Tau, we employ a set of molecular simulations and the Markov state model to determine the kinetics of ensemble of K18. K18 is the microtubule-binding domain of Tau protein and plays a vital role in the microtubule assembly, recycling processes, and amyloid fibril formation.
View Article and Find Full Text PDFSerum Protein Concentration and Serum Protein Fractions in Bottlenose Dolphins under Human Care Using Agarose Gel Electrophoresis.
Animals (Basel)
May 2023
Department of Comparative Biomedicine and Food Science, University of Padova, Viale Dell'Università 16, Legnaro, 35020 Padova, Italy.
Serum protein electrophoresis (SPE) is the most used and reliable method to determine the percentage of serum protein subfractions. The interpretation of the kinetics of total proteins and albumin and globulin fractions is receiving increased attention in wild animals, as well as in domestic animals, due to the possibility of identifying typical pathologic patterns. However, the interpretation of these data had to be performed in light of an appropriate method-and species- specific reference intervals (RIs).
View Article and Find Full Text PDFMeasurement of plasma protein and whole body protein metabolism using [N]glycine in a young adult man - a pilot study.
Isotopes Environ Health Stud
December 2023
Watestr. 44, Leipzig 04279, Germany.
A novel simplified method is presented for the estimation of the metabolism of plasma proteins (albumin, fibrinogen, , and -globulin, glycoprotein) with regard to the whole body protein metabolism in a young male volunteer (22 years, 81 kg body mass). This method is based on multiple oral administration of [N]glycine followed by measurement of N in plasma proteins, total free amino acids, urea and excreted urinary N. The fractional synthesis rate of albumin was estimated to 6.
View Article and Find Full Text PDFMulti-size optimization of macroporous cellulose beads as protein anion exchangers: Effects of macropore size, protein size, and ligand length.
J Chromatogr A
August 2023
Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan University, No.24 South Section 1, Yihuan Road, Chengdu 610065, China. Electronic address:
Multi-size optimization of ion exchangers based on protein characteristics and understanding of underlying mechanism is crucial to achieve maximum separation performance in terms of adsorption capacity and uptake kinetic. Herein, we characterize the effects of three different sizes, macropore size, protein size, and ligand length, on the protein adsorption capacity and uptake kinetic of macroporous cellulose beads, and provide insights into the underlying mechanism. In detail, (1) for smaller bovine serum albumin, macropore size has a negligible effect on the adsorption capacity, while for larger γ-globulin, larger macropores improve the adsorption capacity due to the high accessibility of binding sites; (2) there is a critical pore size (CPZ), at which the adsorption uptake kinetic is minimum.
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