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Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birth.
Placenta
December 2024
Telethon Kids Institute, Wal-yan Respiratory Research Centre, Perth, 6009, Western Australia, Australia.
Introduction: Children with wheeze and asthma present with airway epithelial vulnerabilities, such as impaired responses to viral infection. It is postulated that the in utero environment may contribute to the development of airway epithelial vulnerabilities. The aims of the study were to establish whether the receptors for rhinovirus (RV), respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are expressed in the amniotic membrane and whether the pattern of expression is similar to newborn nasal epithelium.
View Article and Find Full Text PDFHuman amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications.
Hum Cell
January 2025
Department of Metabolism and Endocrinology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its complications. Human amniotic epithelial stem cells (HAESCs), originate from the innermost layer of the placenta closest to the fetus and express stem cell markers in the amniotic membrane's umbilical cord attachment area, which have garnered significant attention. This article critically examines emerging research advancements and potential application values of hAESCs in treating diabetes and its complications.
View Article and Find Full Text PDFMesencephalosynapsis and aqueductal stenosis.
J Neuropathol Exp Neurol
December 2024
Fetal Medicine Unit, Ontario Fetal Center, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Mesencephalosynapsis is characterized by a failure of the dorsal brainstem colliculi to separate into distinct lateral masses (non-cleavage, a.k.a.
View Article and Find Full Text PDFApproaching the sterile womb theory in dogs and cats: A multi-technique investigation.
Theriogenology
February 2025
Department of Veterinary Sciences, University of Turin, 10095, Grugliasco, Italy.
Article Synopsis
- - The study explored bacterial presence in the womb of dogs and cats using various methods like gene sequencing and culture analysis, with samples taken from pregnant animals undergoing surgery.
- - Bacterial sequences were found in all fetal samples, but contamination from controls highlighted the complexity of understanding bacterial diversity and composition in these low-biomass samples.
- - Key findings revealed Moraxella spp. and Burkholderia cepacia in canine and feline placentas, respectively, but the presence of bacterial DNA doesn't imply a functioning fetal microbiome, suggesting that this DNA likely comes from the mother rather than a resident fetus.
Extracellular vesicles of different cellular origin feature distinct biomolecular corona dynamics.
Nanoscale Horiz
December 2024
Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Initially observed on synthetic nanoparticles, the existence of biomolecular corona and its role in determining nanoparticle identity and function are now beginning to be acknowledged in biogenic nanoparticles, particularly in extracellular vesicles - membrane-enclosed nanoparticle shuttling proteins, nucleic acids, and metabolites which are released by cells for physiological and pathological communication - we developed a methodology based on fluorescence correlation spectroscopy to track biomolecular corona formation on extracellular vesicles derived from human red blood cells and amniotic membrane mesenchymal stromal cells when these vesicles are dispersed in human plasma. The methodology allows for tracking corona dynamics under physiological conditions. Results evidence that the two extracellular vesicle populations feature distinct corona dynamics.
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